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Fabrizio Chiodo
Experience & Activities
Fabrizio Chiodo studies carbohydrate-mediated immunological responses mostly in the context of conjugate-vaccines and host-pathogen interactions. He defended his PhD in 2013 in Spain (Applied Chemistry, working on synthetic vaccines and nanotechnology applied to vaccinology), and in 2014 he obtained a personal grant from the Netherlands Organization for Scientific Research working at the Leiden Institute of Chemistry and Leiden University Medical Center. He initiated and strengthened International collaborations in the field of vaccinology especially with the Finlay Institute in Havana (Cuba), where he is appointed as Invited Lecturer at the Faculty of Chemistry. In 2018 he was awarded with a personal grant from the Amsterdam Infection and Immunity Institute working independently at the Y. van Kooyk group. From October 2020 he is a Research Assistant Professor at the Italian National Research Council (CNR) working at the Institute of Biomolecular Chemistry, Naples, keeping his affiliation and position also in Amsterdam.
GlycoScience
GlycoImmunology
Carbohydrate-mediated interactions
Conjugate-vaccines
Innate responses
SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies. Y. Valdes-Balbin, D.Santana-Mederos, L. Quintero, S. Fernandez, L. Rodriguez, B. Sanchez-Ramirez, R. Perez, […], F. Chiodo, F. Paquet, G. Chen, D. G Rivera, D. Garcia-Rivera, V. Verez-Bencomo. 2021, ACS Chemical Biology, 16, 7, 1223–1233
Q. Zhu, Z. Shen, F. Chiodo, S. Nicolardi, A. Molinaro, A. Silipo, B. Yu. Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus. 2020, Nature Communications, 11, 4142
Q. Zhang, A. Gimeno, D. Santana, Z. Wang, Y. Valdes-Balbin, L. Rodriguez-Noda, T. Hansen, L. Kong, M. Shen, H. Overkleeft, V. Verez-Bencomo, G. van der Marel, J. Jiménez-Barbero, F. Chiodo, J. Codée. Synthetic, zwitterionic Sp1-oligosaccharides adopt a helical structure crucial for antibody interaction. 2019, ACS Central Science, 5, 1407-1416
S. Nicolardi, Y. van der Burgt, M. Wuhrer, J. Codee. C. H. Hokke, F. Chiodo. Structural characterization of bio-functionalized gold nanoparticles by ultrahigh resolution mass spectrometry. 2017, ACS Nano, 11, 8257-8264
M. Marradi, F. Chiodo, I. García, S. Penadés. Glyconanoparticles as multifunctional and multimodal carbohydrate systems. 2013, Chemical Society Reviews, 42, 4728-4745
MAIN RESEARCH SITE, POZZUOLI (NA)
fabrizio.chiodo@cnr.it
f.chiodo@amsterdamumc.nl
