Technological platforms and research infrastructures
The institute’s infrastructures are particularly suitable for the analysis of single metabolites (marker analysis) and molecular pools (metabolomics, glycomics and lipidomics), for the characterization of the molecular structure of new bioactive compounds, for the study of biological properties (cellular and enzymatic assays, ex vivo models, animal models) and the mechanism of action of bioactive compounds, the synthesis and functionalization of organic molecules, the study of the mechanism and kinetics of reactions of industrial interest. For the pharmaceutical sector, the activities dedicated to the analysis, synthesis and biological evaluation of small bioactive organic molecules are able to support studies of lead compounds and preclinical development of lipids, natural products, peptides and biomarkers for oncology, immunology and neuroscience. The Institute also makes available a collection of natural molecules and extracts and a database with information on molecules discovered, synthesized or characterized at our offices. In the biotechnology field, the Institute conducts research in the development and implementation of processes based on extremophilic and whole-cell enzymes for the biological mitigation of CO2 and for the production of hydrogen, food ingredients and functional and/or bioactive compounds from the conversion of natural matrices and residues agro-food.
The Institute has a proven experience in analyzing, preparing and evaluating the biological properties of small organic molecules. We invest time in the interpretation of complex spectral data to identify our compounds from natural sources, developing biological models to demonstrate their efficacy on health and understanding their biological role, implementing synthetic and biosynthetic pathways for their sustainable production. In line with these activities, the infrastructures of the Institute of Biomolecular Chemistry constitute an updated technological platform for the study of small molecules and/or biotechnological processes related to the production of functional molecules.
The Institute is further strengthening the possibility of supporting SMEs and large companies through the renewal of the large equipment present in the various offices in Pozzuoli, Sassari, Catania and Padua. This renewal is already underway thanks to the Infrastructure Program of the CNR and funding of competitive research projects and by virtue of the collaboration with the UMI agreement between CNR and the University of Laval (Canada) it can support studies on the microbiota from the analyses of chemical mediators to metagenomics approaches. Furthermore, in collaboration with the Bicocca University and the Federico II University of Naples, the ICB is handling the candidacy for the entry of the CNR into the European Infrastructure ESFRI EU-OPENSCREEN, providing services and skills as ASSAYS SUPPLIER. (molecular biologists, microbiologists, biochemists) and as a SUPPLIER OF MOLECULES (chemicals) for applied research and support to the European industry in the pharmaceutical, nutraceutical, agro-food and cosmetic fields.