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Dr. Abbamondi graduated in “Pharmaceutical Chemistry and Technology” at the Federico II University of Naples in 2009, with an experimental thesis on secondary metabolites of plant origin. In 2013 he obtained the title of Doctor of Research in “Environment, Resources and Sustainable Development” at the Parthenope University of Naples, joint PhD with Hasselt University (Belgium), discussing the thesis on “The role of Quorum Sensing in marine bacteria, Archaea and inter-kingdom communication”. Academic degree according to the Flemish higher education structure: “Doctor of Science: Biology”. Between 2010 and 2019 he actively collaborated with the CNR-ICB and the CNR-IPCB of Pozzuoli (NA), with abroad experience as Researcher in multiple countries including Belgium (Hasselt University), Morocco (Sidi Mohamed Ben Abdellah University) and the Antarctica (XXXIV Antarctic Expedition). He also worked as a post-doc at Hasselt University (Belgium, 2015) on “The role of Quorum Sensing in biofilm formation of selected strains” and at Toulon University (France, 2016) on the “Structural characterization of exopolysaccharides produced by marine biofilm-forming bacteria”. Since February 1st 2022 he is a III level Researcher at the CNR-ICB for the Strategic Area of Chemistry and Materials for Health and Life Sciences.

Skills Chemistry of natural products
Biological activity assays
Microorganisms associated with marine sponges and plants
Quorum sensing
Evaluation of nutritional properties and design of new tomato hybrids
Plant Growth Promotion
Extremophilic microorganisms Publications

1) Abbamondi GR, Tommonaro G, Weyens N, Thijs S, Sillen W, Gkorezis P, Iodice C, de Melo Rangel W, Nicolaus B, Vangronsveld J (2016) Plant growth-promoting effects of rhizospheric and endophytic bacteria associated with different tomato cultivars and new tomato hybrids. Chem. Biol. Technol. Agric., 3:1. https://doi.org/10.1186/s40538-015-0051-3

2) Tommonaro G, Abbamondi GR, Iodice C, Tait K, De Rosa S (2012) Diketopiperazines Produced by the Halophilic Archaeon, Haloterrigena hispanica, Activate AHL Bioreporters. Microbial Ecology, 63(3):490-5. https://doi.org/10.1007/s00248-011-9980-y

3) Sillen, W., Thijs, S., Abbamondi, G. R., De La Torre Roche, R., Weyens, N., White, J. C., & Vangronsveld, J. (2020). Nanoparticle treatment of maize analyzed through the metatranscriptome: compromised nitrogen cycling, possible phytopathogen selection, and plant hormesis. Microbiome, 8(1), 127. https://doi.org/10.1186/s40168-020-00904-y

4) Başaran, T. I., Berber, D., Gökalsın, B., Tramice, A., Tommonaro, G., Abbamondi, G. R., Erginer Hasköylü, M., Toksoy Öner, E., Iodice, C., & Sesal, N. C. (2020). Extremophilic Natrinema versiforme Against Pseudomonas aeruginosa Quorum Sensing and Biofilm. Frontiers in microbiology, 11, 79. https://doi.org/10.3389/fmicb.2020.00079

5) Poli A, Di Donato P, Abbamondi GR and Nicolaus B (2011) Synthesis, production and biotechnological applications of exopolysaccharides (EPSs) and poly-hydroxyalkanoates (PHAs) by Archaea. Archaea, Article ID 693253, 13 pages. https://doi.org/10.1155/2011/693253

Contact MAIN RESEARCH SITE, POZZUOLI (NA)

   g.r.abbamondi@icb.cnr.it

   (+39) 0818675192

Orcid: https://orcid.org/ 0000-0003-4772-3989

Researcher-id: https://publons.com/researcher/B-9343-2014/ Researchgate View curriculum

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Elisabetta Alberico obtained her Master of Science – Chemistry (with honours) at the University of Sassari, Italy and her Ph. D. (Summa cum Laude) at the Rheinisch-Westfälische Technische Hochschule in Aachen, Germany. She has been research associate at the University of Ottawa, Canada, in the group of Prof. Howard Alpern, working at the regio- and stereoselective synthesis of key 1-methyl carbapenem intermediates via hydroformylation using a zwitterionic rhodium catalyst. Since 2001 she is researcher at the Institute of Biomolecular Chemistry ICB-CNR in Sassari, Italy and, since 2011, she is associate researcher in the group of Prof. Matthias Beller at the Leibniz Institut für Catalyse, Rostock, Germany. She is co-author of 48 publications on international peer-reviewed journals (Web of Science, September 2021) and 5 book chapters. She has been reviewer for ACS Catalysis, Organometallics, Inorganic Chemistry, Chemical Science, ChemCatChem, Asian Journal of Organic Chemistry, Chemistry Select, Journal of Molecular Catalysis, Journal of Molecular Catalysis A: Chemical, Journal of Organometallic Chemistry. Her research interests are devoted to the design and synthesis of novel homogeneous catalysts based on noble and non-noble transition metals, for hydrogenation, transfer hydrogenation and dehydrogenation reactions; to the development of homogeneous catalytic processes for the reduction of multiple bonds as key steps in the synthesis of molecules of industrial relevance; to the homogeneously catalyzed hydrogen generation from renewables (methanol, formic acid) under mild conditions; to the investigation into the mechanism of the reactions catalyzed by the developed catalysts.

Skills Homogeneous Catalysis
Hydrogen
Renewable Energy
Organometallic Synthesis Publications

1. Alberico E.,* Leischner T., Junge H.,* Kammer A., Sang R., Seifert J., Baumann W., Spannenberg A., Junge K., Beller M.* HCOOH disproportionation to MeOH promoted by molybdenum PNP complexes, Chem. Sci. 2021 DOI: 10.1039/d1sc04181a

2. Papa V., Cabrero-Antonino J. R., Alberico E., Spannenberg A., Junge K., Junge H. Beller M.* Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese–PNN pincer complex, Chem. Sci., 2017, 8, 3576, DOI: 10.1039/c7sc00138j

3. Alberico E., Lennox A. J. J., Vogt L. K., Jiao H., Baumann W., Drexler H.-J., Nielsen N., Spannenberg A., Marek P. Checinski M. P., Junge H., Beller M.* Unravelling the Mechanism of Basic Aqueous Methanol Dehydrogenation Catalyzed by Ru−PNP Pincer Complexes, J. Am. Chem. Soc. 2016, 138, 14890−14904, DOI: 10.1021/jacs.6b05692

4. Nielsen M., Alberico E., Baumann W., Drexler H.-J., Junge H., Gladiali S., Beller M.* Low-temperature aqueous-phase methanol dehydrogenation to hydrogen and carbon dioxide, Nature, 2013, 495, 85-89, DOI:10.1038/nature11891

5. Alberico E., Sponholz P., Cordes C., Nielsen M., Drexler H.-J., Baumann W., Junge H., Beller M.* Selective Hydrogen Production from Methanol with a Defined Iron Pincer Catalyst under Mild Conditions, Angew. Chem. Int. Ed. 2013, 52, 14162 –14166, DOI: 10.1002/anie.201307224

Contacts    RESEARCH SITE OF SASSARI

   elisabetta.alberico@cnr.it – elisabetta.alberico@catalysis.de

  PEC: elisabetta.alberico@pec.it

  (+39) 0792841206

ORCID: 0000-0002-1143-6032

Researcher ID: C-5378-2015 Catalysis Publons View curriculum

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Biography Skills Publications Contact Biography Skills Publications Contact    MAIN RESEARCH SITE, POZZUOLI (NA)

   pamodeo@icb.cnr.it

  (+39) 081 8675072 View curriculum

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Biography Skills Publications Contacts Biography

1990, B.S. Chemistry (with top marks), University of Naples “Federico II”, Italy

1996, Ph.D. Biochemistry, University of Naples “Federico II”, Italy

From 27 December 2001, Researcher at the Institute of Biomolecular Chemistry- National Research Council of Italy

RECENT SCIENTIFIC INTERESTS

• Pharmacological chaperones: identification of targets and development of drugs. Fabry disease and PMM2-CDG (congenital disorder of glycosylation Ia or Jaken disease).

• Purification and characterization of proteins/enzymes for biotechnological applications: Glycosyl hydrolases from marine organisms and exploitation of their potential for biotechnological applications (fine and pharmaceutical chemistry, agrochemistry, and so on). Biomolecules (proteins, lipids, ect.) from biomaterials.

• Application of NMR spectroscopy to metabolomic studies and to structural characterization of proteins and peptides.

Skills Pharmacological chaperones
Protein Expression and Purification
Enzymatic Assay
Peptide/Protein Structure
Thermal Shift Assay
NMR
Fabry disease
PMM2-CDG Publications

1. Monticelli M, Hay Mele B, Benetti E, Fallerini C, Baldassarri M, Furini S, Frullanti E, Mari F, GEN-COVID Multicenter Study, Andreotti G, Cubellis MV, Renieri A. Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women. Genes. 2021; 12(4):596. https://doi.org/10.3390/genes12040596

2. Monticelli M, Liguori L, Allocca M, Andreotti G*, Cubellis MV. β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG. Int. J. Mol. Sci. 2019, 20(17), 4164. https://doi.org/10.3390/ijms20174164

3. Citro V, Cimmaruta C, Monticelli M, Riccio G, Hay Mele B, Cubellis MV, Andreotti G. The Analysis of Variants in the General Population Reveals That PMM2 Is Extremely Tolerant to Missense Mutations and That Diagnosis of PMM2-CDG Can Benefit from the Identification of Modifiers. Int J Mol Sci. 2018 Jul 30;19(8). doi: 10.3390/ijms19082218

4. Citro V, Cammisa M, Liguori L, Cimmaruta C, Lukas J, Cubellis MV, and Andreotti G. The Large Phenotypic Spectrum of Fabry Disease Requires Graduated Diagnosis and Personalized Therapy: A Meta-Analysis Can Help to Differentiate Missense Mutations. Int. J. Mol. Sci. 2016, 17(12), 2010; doi:10.3390/ijms17122010

5. Citro V, Peña-Garcia J, den-Haan H, Perez-Sanchez H, Del Prete R, Liguori L, Cimmaruta C, Lukas J, Cubellis MV, Andreotti G. Identification of an Allosteric Binding Site on Human Lysosomal Alpha-Galactosidase Opens the Way to New Pharmacological Chaperones for Fabry Disease. PLOS ONE | DOI:10.1371/journal.pone.0165463 October 27, 2016

Contacts    MAIN RESEARCH SITE, POZZUOLI (NA)

   gandreotti@icb.cnr.it

   PEC: gandreotti@pec.it

   (+39) 081 8675241

ORCID: https://orcid.org/0000-0002-1594-0156
Scopus Author ID: 7004848704
Web of Science ResearcherID: AAX-8952-2020 View curriculum

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Biography Skills Publications Contacts Biography Skills Publications Contacts   RESEARCH SITE OF CATANIA    sergio.argento@cnr.it   (+39) 095 7338111 View curriculum

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EDUCATION 1992 Degree in Chemistry, Department of Organic Chemistry, University of Padova, Italy.

CURRENT POSITION

2021 Researcher at CNR, Institute of Biomolecular Chemistry, Padova Unit, Padova, Italy.

INSTITUTIONAL RESPONSIBILITIES

2019 to date: Advisory Committee, Institute of Biomolecular Chemistry 2010 to date: Treasurer (Economo), Institute of Biomolecular Chemistry.

TEACHING ACTIVITIES

2011 to date: Organic and Bioorganic Chemistry, degree course in Biotechnology, University of Padova 2001 to date: supervision of undergraduate and PhD students.

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

Member of the ACS, APS, EPS, SCI, ItPS.

SCIENTIFIC INTERESTS focus on peptides containing non-proteinogenic amino acids to explore their antimicrobial / antitumor activity and to study the mechanisms of interaction with biological membranes. Another relevant focus is the synthesis and conformational analysis of peptides with a rigid and well-defined three-dimensional structure to be used as spacers and templates.

The research activities are aimed at: i) understanding the structure/function relationship in bioactive peptides with antimicrobial and anticancer activities ii) elucidating the charge/electron transfer processes in proteins by use of model peptides with well-defined 3D-structure.

Skills Peptide synthesis
Conformation
Circular dichroism
IR spectroscopy
NMR
EPR Publications

1. Biondi, B.; Cardena, R.; Bisello, A.; Schiesari, R.; Cerveson, L.; Facci, M.; Rancan, M.; Formaggio, F.; Santi, S., Flat, Ferrocenyl-Conjugated Peptides: A Combined Electrochemical and Spectroscopic Study. ChemElectroChem (2021) 8, 2693-2700.

2. Guryanov, I.; Korzhikov-Vlakh, V.; Bhattacharya, M.; Biondi, B.; Masiero, G.; Formaggio, F.; Tennikova, T.; Urtti, A., Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor. J. Med. Chem. (2021) 64, 10900-10907.

3. Golysheva, E. A.; Boyle, A. L.; Biondi, B.; Ruzza, P.; Kros, A.; Raap, J.; Toniolo, C.; Formaggio, F.; Dzuba, S. A., Probing the E/K Peptide Coiled-Coil Assembly by Double Electron–Electron Resonance and Circular Dichroism. Biochemistry (2021) 60, 19-30.

4. Kubitzky, S.; Venanzi, M.; Biondi, B.; Lettieri, R.; De Zotti, M.; Gatto, E., A pH-Induced Reversible Conformational Switch Able to Control the Photocurrent Efficiency in a Peptide Supramolecular System. Chem.-Eur. J. (2021) 27, 2810-2817.

5. Santi, S.; Bisello, A.; Cardena, R.; Tomelleri, S.; Schiesari, R.; Biondi, B.; Crisma, M.; Formaggio, F., Flat, Cα,β-Didehydroalanine Foldamers with Ferrocene Pendants: Assessing the Role of α-Peptide Dipolar Moments. ChemPlusChem (2021) 86, 723-730.

Contacts    RESEARCH SITE OF PADOVA

   barbara.biondi@icb.cnr.it – barbara.biondi@unipd.it

  (+39) 049 8275254

ORCID: 0000-0003-2393-7333 WoS

ResearcherID: AAT-6448-2021 View curriculum

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Daniela Biondi is currently Researcher working since 1994 in Catania at the Istituto di Chimica Biomolecolare (I.C.B.) belonging to Consiglio Nazionale delle Ricerche, Italy. She graduated with honors in Pharmacy at the University of Catania discussing a thesis on “Sintesi e reattività di eteri ciclici funzionalizzati mediante ciclo addizioni intramolecolari di nitrilossidi” . From 1991 to 1993 she worked granted by a research fellowship at the CNR-Istituto per lo Studio delle Sostanze Naturali

Skills Essential oils
Green chemistry
Antioxidant activity
Nutrition
Olive Mill wastewater
Vegetable flours
Oxygenases
Terpenes Publications

1. Biondi D., Rocco C., Ruberto G., New Dihydrostilbene derivative from the leaves of Glycyrrhiza glabra and evaluation of their antioxidant activity, J. of Natural Products (2003), 66(4) 477-480. https://pubs.acs.org/doi/pdf/10.1021/np050034q

2. Jacques Simpore; Frederic Zongo, Fatoumata Kabore, Deleli Dansou; Augustin Bere; Jean-Baptiste Nikiema, Salvatore Pignatelli; Daniela M.Biondi; Giuseppe Ruberto; Salvatore Musumeci. Nutrition Rehabilitation of HIV-Infected and HIV- Negative undernourished children utilizing Spiruline, Ann. Nutrition & Metabolism 2005, 49, 373-380. https://pubmed.ncbi.nlm.nih.gov/16219988/

3. G. Fava, M.D. Di Mauro, M. Spampinato, D. Biondi, G. Gambera, G. Centonze, R. Maggiore, N. D’Antona, Hydroxytyrosol Recovery from Olive Mill Wastewater: Process Optimization and Development of a Pilot Plant, CLEAN Soil Air Water (2017), 45, (4) 1600042  

https://onlinelibrary.wiley.com/doi/full/10.1002/clen.201600042

4. C.Sanfilippo, A.Paterna, D.M.Biondi, A,Patti, Lyophilized extract from vegetable flours as valuable alternatives to purified oxygenases for the synthesis of oxylipins, Bioorganic Chemistry , 2019, 93,103325

https://www.sciencedirect.com/science/article/

5. D.M.Biondi, C. Sanfilippo, A. Patti, Stereospecific Epoxidation of limonene Catalyzed by Peroxygenase from Oat Seeds, Antioxidants, 2021, 10, 1461 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469233/

Contact    RESEARCH SITE OF CATANIA

   daniela.biondi@icb.cnr.it – danielabiondister@gmail.com

   PEC: danielamaria.biondi@pec.it

   (+39) 095 7338332

ORCID: https://orcid.org/0000-0002-9567-3341

Scopus ID: 6603712495 View curriculum

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Biography Skills Publications Contacts Biography Skills Publications Contacts   MAIN RESEARCH SITE, POZZUOLI (NA))    mariarita.canfora@icb.cnr.it   (+39) 0818675079 View curriculum

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   mcarbone@icb.cnr.it

   (+39) 081 8675227; 0818675176 View curriculum

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Paola Carta was born in Sassari on October 18, 1972. She graduated with honors in Chemistry and Pharmaceutical Technologies (CTF) in 1996 at the University of Sassari. From 1997 to 2000 she worked as a researcher at the CNR Institute for the Application of Advanced Chemical Techniques to Agrobiological Problems in Sassari. In 2005 she obtained her PhD in Organic Chemistry at King’s College London and in 2004 she participated as Visiting PhD student at the Institute of Organ-Element Compounds at the Russian Academy of Sciences, Moscow. From 2005 to 2006 she carries out research work as postdoc at the Universitè Pierre et Marie Curie in Paris. She returned to Italy in 2006 and until 2018 she worked as researcher at ICB UOS Sassari, Porto Conte Ricerche srl (Alghero, SS) and for the NeED Pharmaceuticals s.r.l. Since 2018 she holds a permanent researcher position (III level) at the Institute of Biomolecular Chemistry UOS-Sassari.

Main Interests:

• Design, synthesis and study of multifunctional hydroxylated biphenyl derivatives of natural origin.

• Organic synthesis of natural and natural-like small molecules with potential biological/pharmacological activity and analogues of natural products.

• Study, extraction and characterization of active ingredients from biomass through environmentally sustainable methods.

Skills Synthetic Organic Chemistry
Natural Compounds
Hydroxylated Biphenyls
C2 symmetry
Green chemistry Publications

• Prenylated Trans-Cinnamic Esters and Ethers against Clinical Fusarium spp.: Repositioning of Natural Compounds in Antimicrobial Discovery.

Safa Oufensou, Stefano Casalini, Virgilio Balmas, Paola Carta, Wiem Chtioui, Maria A. Dettori, Davide Fabbri, Quirico Migheli and Giovanna Delogu. Molecules 2021, 26, 658. 

• Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress.

Kancheva, V.D.; Dettori, M.A.; Fabbri, D.; Alov, P.; Angelova, S.E.; Slavova-Kazakova, A.; Carta, P.; Menshov, V.A.; Yablonskaya, O.I.; Trofimov, A.V.; Tsakovska, I.; Saso, L. Antioxidants 2021, 10, 624.

• Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes.

Dettori, M.A.; Fabbri, D.; Dessì, A.; Dallocchio, R.; Carta, P.; Honisch, C.; Ruzza, P.; Farina, D.; Migheli, R.; Serra, P.A.; Pantaleoni, R.A.; Fois, X.; Rocchitta, G.; Delogu, G.  Molecules 2020, 25, 2709.

• Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance.

Oufensou, S.; Scherm, B.; Pani, G.; Balmas, V.; Fabbri, D.; Dettori, M.A.; Carta, P.; Malbrán, I.; Migheli, Q.; Delogu, G.

PLoS ONE 2019, 14(9), e0221249. Synthesis of Magnolol and Honokiol Derivates and their Effect against Hepatocarcinoma cells.

Margherita Maioli; Valentina Basoli; Paola Carta; Davide Fabbri; Maria Antonietta Dettori; Sara Cruciani; Pier Andrea Serra; Giovanna Delogu.  PLoS ONE, 2018, 1-21. 

Contacts   RESEARCH SITE OF SASSARI

   p.carta@icb.cnr.it – paola.carta@cnr.it

   (+39) 079 2841119

ORCID: 0000-0001-8749-6093
Web of Science ResearcherID: H-2026-2013 Researchgate Publons View curriculum

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Dr Daniela Castiglia graduated in Biology cum laude at the University of Naples, Federico II in 2008. Dr Castiglia earned a PhD in Applied Biology at the same university in 2012 discussing a thesis entitled “Cytosolic Glucose-6P dehydrogenase in barley: Overexpression, characterization and regulation by biotic stress and sugar sensing”, working for the Plant Physiology group (Principal Investigator, Prof. Sergio Esposito). The research activity focused on the molecular and biochemical characterization of proteins involved in the primary metabolism of plants and in defense mechanisms counteracting biotic and abiotic stresses. During her PhD programme, Dr. Castiglia was a guest at the Plant Biology Institute of the University of Zurich, hosted by Prof. Beat Keller. From April 2013, Dr Castiglia was postdoctoral researcher at the CNR-IBBR of Portici, where her research activity focused on biotechnological applications of recombinant proteins expressed in plants. These activities were mainly focused on industrial, energetic and bioconversion processes (Principal Investigator, Dr. Nunzia Scotti). In July 2020, Dr Castiglia started work as a Researcher at the National Research Council of Italy, Institute of biomolecular chemistry, (CNR-ICB), in Pozzuoli. She is currently working on biotechnological applications of diatoms.

Skills Microalgae Diatoms Chemicalbiology Chloroplast transformation Recombinant proteins Publications

1_Cardi M*, Castiglia D*, Ferrara M*, Guerriero G*, Chiurazzi M, Esposito S. (2015) The effects of salt stress cause a diversion of basal metabolism in barley roots: possible different roles for glucose-6-phosphate dehydrogenase isoforms. *: joint first authors. Plant Physiology and Biochemistry. 86: 44-54 DOI: 10.1016/j.plaphy.2014.11.001

2_Basile A, Sorbo S, Cardi M, Lentini M, Castiglia D, Cianciullo P, Conte B, Loppi S, Esposito S. (2015). Effects of heavy metals pollution on ultrastructure and HSP70 induction, in Lemna minor L. exposed along Sarno River (Italy). Ecotoxicology and Environmental Safety. 114: 93-101 DOI: 10.1016/j.ecoenv.2015.01.009

3_Castiglia D, Sannino L, Marcolongo L, Ionata E, Tamburino R, De Stradis A, Cobucci-Ponzano B, Moracci M, La Cara F, Scotti N. (2016) High-level expression of thermostable cellulolytic enzymes in tobacco transplastomic plants and their use in hydrolysis of an industrially pretreated Arundo donax L. biomass. Biotechnology for Biofuels, 9(1), 154. DOI:10.1186/s13068-016-0569-z 4_Castiglia D, Leone S, Tamburino R, Sannino L, Fonderico J, Melchiorre C, Carpentieri A, Grillo S, Picone D, Scotti N (2018) High-level production of single chain monellin mutants with enhanced sweetness and stability in tobacco chloroplasts. Planta 248, 465–476. DOI: https://doi.org/10.1007/s00425-018-2920-z 5_Castiglia D, Landi S, Esposito S. (2021) Advanced Applications for Protein and Compounds from Microalgae. Plants (Basel) 10(8):1686. DOI: https://doi.org/10.3390/plants10081686 Contacts    MAIN RESEARCH SITE, POZZUOLI    d.castiglia@icb.cnr.it   (+39) 081 867 5182 ORCID: https://orcid.org/0000-0002-9794-8644 MDPI Researchgate View curriculum

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Milena Casula is a researcher of the Institute of Biomolecular Chemistry (ICB) CNR, and she collaborates with the Institute for Genetic and Biomedical Research, CNR. She received her Academic Degree in Biological Science at the University of Sassari in 1999 and her PhD Degree in Biochemistry, Biology and Molecular Biotechnology at the University of Sassari in 2008. She has extensive background in biological sciences combined with a strong practical work experience in basic research, mainly focused on oncology studies. She worked abroad at the Doctor Negrin University Hospital of Gran Canaria studying the role of Wnt/beta-catenin and Toll Like Receptors Signaling Pathways in the acute lung injury and acute respiratory distress syndrome, testing new biological molecules on cell culture model for sepsis-related processes. She is the author of several scientific articles (Web of Science H-index: 20) and she is currently involved in the analysis of circulating tumor DNA (ctDNA) using highly sensitive methods such as Next Generation Sequencing and Droplet Digital PCR.

Skills Molecular oncology
Immunohistochemistry (IHC)
Immunocytochemistry (ICC)
WesternBlottin
Next Generation Sequencing technology (IonTorrent, Illumina)
Manually designing of targeted NGS panels
Realtime PCR
Droplet Digital™ PCR (ddPCR™) Publications

1. Calabrò L, Rossi G, Morra A, Rosati C, Cutaia O, Daffinà MG, Altomonte M, Di Giacomo AM, Casula M, Fazio C, Palmieri G, Giannarelli D, Covre A, Maio M. Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT-MESO-1 study. Lancet Respir Med. 2021 Sep;9(9):969-976. doi: 10.1016/S2213-2600(21)00043-6. Epub 2021 Apr 9. PMID: 33844995.

2. Ottaviano M, Giunta EF, Rescigno P, Pereira Mestre R, Marandino L, Tortora M, Riccio V, Parola S, Casula M, Paliogiannis P, Cossu A, Vogl UM, Bosso D, Rosanova M, Mazzola B, Daniele B, Palmieri G, Palmieri G. The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something? Int J Mol Sci. 2021 Jul 2;22(13):7160. doi: 10.3390/ijms22137160. PMID: 34281219; PMCID: PMC8267694.

3. Palmieri G, Rozzo CM, Colombino M, Casula M, Sini MC, Manca A, Pisano M, Doneddu V, Paliogiannis P, Cossu A. Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy? Front Oncol. 2021 May 5; 11:666624. doi: 10.3389/fonc.2021.666624. PMID: 34026645; PMCID: PMC8132875.

4. Vanni I, Casula M, Pastorino L, Manca A, Dalmasso B, Andreotti V, Pisano M, Colombino M; Italian Association for Cancer Research (AIRC) Study Group, Pfeffer U, Tanda ET, Rozzo C, Paliogiannis P, Cossu A, Ghiorzo P, Palmieri G; Italian Melanoma Intergroup (IMI). Quality assessment of a clinical next-generation sequencing melanoma panel within the Italian Melanoma Intergroup (IMI). Diagn Pathol. 2020 Dec 14;15(1):143. doi: 10.1186/s13000-020-01052-5. PMID: 33317587; PMCID: PMC7737361.

5. Casula M, Paliogiannis P, Ayala F, De Giorgi V, Stanganelli I, Mandalà M, Colombino M, Manca A, Sini MC, Caracò C, Ascierto PA, Satta RR; Melanoma Unit of Sassari (MUS), Lissia A, Cossu A, Palmieri G; Italian Melanoma Intergroup (IMI). Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study. BMC Cancer. 2019 Aug 5;19(1):772. doi: 10.1186/s12885-019-5984-7. PMID: 31382929; PMCID: PMC6683413.

Contacts   RESEARCH SITE OF SASSARI

   milena.casula@cnr.it – casulam@yahoo.it

   PEC: casulam@pec.it

  Cell (+39) 3421596475

Skype ID: milena. casula73
ORCID: https://orcid.org/0000-0002-5079-9864
Web of Science Researcher ID: AAA-7461-2019
Scopus Author ID: 7003794527 View curriculum

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