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  RESEARCH SITE OF SASSARI

  mariaantonietta.dettori@cnr.it

  (+39) 079 2841224

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Vincenzo Di Marzo’s research activity has been dedicated to the understanding of the mechanisms of chemical communication between cells. His scientific career took an important turn when he began to study the biology of the chemical signals that act in our body on the same receptors as delta9-tetrahydrocannabinol (THC), the psychotropic/euphoric component of marijuana. These molecules, that he named endocannabinoids, have a crucial pleiotropic function as pro-homeostatic signals by regulating the function of other chemical signals in our organism. Any therapeutic tool – including some cannabinoids from Cannabis – that regulates either the tissue concentration or the action of endocannabinoids, can theoretically be used to treat diseases such as neuropsychiatric, neuroinflammatory and metabolic disorders. His over 750 publications on these topics gained Di Marzo a stable place in the list of about 6000 Highly Cited world scientists since 2014. He currently studies the chemical communication between the cells of our body and the microorganisms that stably populate it: the microbiome. As Director of the Joint International Unit for the Study of the Microbiome, between the CNR and the Université Laval in Quebec City (www.umilaval.cnr.it), Canada, he coordinates experiments on the interactions between the intestinal microbiome and endocannabinoids.

Skills

Chemical signalling


Bioactive lipids

Endocannabinoids

Endovanilloids

Cannabinoids

TRP
Channels

Microbiome

Publications

1. Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, Piscitelli F, Gazzerro E, Busetto G, Carrella D, Capasso R, Puri PL, Minchiotti G, Di Marzo V. Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. Nat Commun. 2018;9(1):3950. https://pubmed.ncbi.nlm.nih.gov/30262909/

2. Cristino L, Busetto G, Imperatore R, Ferrandino I, Palomba L, Silvestri C, Petrosino S, Orlando P, Bentivoglio M, Mackie K, Di Marzo V. Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. Proc Natl Acad Sci U S A. 2013;110(24):E2229-38. https://pubmed.ncbi.nlm.nih.gov/23630288/

3. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V. Proc Natl Acad Sci U S A. 2002;99(12):8400-5 https://pubmed.ncbi.nlm.nih.gov/12060783/

4. Leptin-regulated endocannabinoids are involved in maintaining food intake. Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G. Nature. 2001 Apr 12;410(6830):822-5. https://pubmed.ncbi.nlm.nih.gov/11298451/

5. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 1994;372(6507):686-91. https://pubmed.ncbi.nlm.nih.gov/7990962/

Contact

   MAIN RESEARCH SITE, POZZUOLI (NA)

  vincenzo.di-marzo.1@ulaval.ca

   (+39) 081 8675024

ORCID:
https://orcid.org/0000-0002-1490-3070

CERC-MEND ERG Umilaval View curriculum Myhealthywaist

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2021-today: Senior researcher at CNR-Institute of Biomolecular Chemistry (ICB), Pozzuoli (NA) Italy

2009-2020: Staff Researcher at CNR-Institute of Biomolecular Chemistry (ICB), Pozzuoli (NA) Italy

The research activity, in the field of green chemistry and processes for sustainability, is framed in the following topics:

• Chemical studies of microbial metabolism for the biotechnological development of sustainable bioprocesses
• Production of bioenergy (biohydrogen and biodiesel) and added-value molecules through biological processes in hyper-thermophilic bacteria and marine microalgae
• Capture and valorization of CO2 through microbial platforms
• Isolation, structure elucidation, imaging and biosynthesis of small molecules with functional roles

Responsible for the CNR of numerous National and European projects, including EU Project EUREMAP (2024-2026 G.A. n. 101131663) “European Research Infrastructures for Marine Bioprospecting”, EU Project BioRECO2VER (2018-2021, G.A. n. 760431,) ”Biological routes for CO2 conversion into chemical building blocks” and the Project PON01_02740 SIBAFEQ (2011-2015) “Integrated exploitation of algal biomass in a quality energy chain”. Author of 102 scientific publications in international journals, H-index 29, and 1 European Patent. She recently spent three weeks in the laboratories of Prof. Zoltan Takats, Imperial College of London, within the program Short Term Mobility (CNR-STM) 2024. Invited speaker and relator at least of 15 international congresses, and Member of the Scientific Board at least 8 International Congresses. Member of the ICB Institute Council (CdI) since 2019. Tutor of 6 post-Docs, 5 PhDs, 3 Internships, 6 Degree Theses. 

Researcher unique identifiers: Scopus Author ID: 56688544700; Web of Science ID: AAW-8651-2020; ORCID: 0000-0002-6821-6962

Skills

Microbial metabolism


Vio-organic chemistry


Metabolic engineering


Structural elucidation by NMR and MS


Cultivation of marine microalgae and hyper-thermophilic anaerobic bacteria

Publications

D’Ippolito Giuliana*, Landi Simone, Esercizio Nunzia, Lanzilli Mariamichella, Vastano Marco, Dipasquale Laura, Pradhan, Nirakar, Fontana Angelo. CO2-Induced Transcriptional Reorganization: Molecular Basis of Capnophillic Lactic Fermentation in Thermotoga neapolitana. FRONTIERS IN MICROBIOLOGY, 2020, Volume: 11, Article Number: 171. (ISSN): 1664-302X. doi: 10.3389/fmicb.2020.00171

Vella Filomena Monica, Sardo Angela, Gallo Carmela, Landi Simone, Fontana Angelo,

D’Ippolito Giuliana*. Annual outdoor cultivation of the diatom Thalassiosira weissflogii: productivity, limits and perspectives. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2019, Volume: 42, Article Number: 101553. (ISSN): 2211-9264. doi: 10.1016/j.algal.2019.101553

Gallo Carmela, d’Ippolito Giuliana*, Nuzzo Genoveffa, Sardo Angela, Fontana Angelo. Autoinhibitory sterol sulfates mediate programmed cell death in a bloom-forming marine diatom. NATURE COMMUNICATIONS, 2017, Volume: 8, Article Number: 1292. (ISSN): 2041-1723. doi: 10.1038/s41467-017-01300-1

D’Ippolito Giuliana*, Sardo Angela, Paris Debora, Vella Filomena Monica, Adelfi Maria Grazia, Botte Pierpaolo, Gallo Carmela, Fontana Angelo. Potential of lipid metabolism in marine diatoms for biofuel production. BIOTECHNOLOGY FOR BIOFUELS, 2015, Volume: 8, Article Number: 28. (ISSN): 1754-6834. doi: 10.1186/s13068-015-0212-4

D’Ippolito Giuliana, Dipasquale Laura, Fontana Angelo. Recycling of Carbon Dioxide and Acetate as Lactic Acid by the Hydrogen-Producing Bacterium Thermotoga neapolitana. CHEMSUSCHEM, 2014, Volume: 7, Issue: 9, Pages: 2678-2683. (ISSN): 1864-5631. doi: 10.1002/cssc.201402155D

Contacts

  MAIN RESEARCH SITE, POZZUOLI (NA)

  giuliana.dippolito@cnr.it

   (+39) 081 8675096

Scopus Author ID: 56688544700

Web of Science ID: AAW-8651-2020;

ORCID:
0000-0002-6821-6962

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Carmelo Drago graduated in chemistry at the University of Catania on 21st December 2001 (grade, 110/110). In April 2002 he started a PhD at the Chemistry Department of Sheffield University (U.K.) working on a project entitled “Combinatorial Approaches to Catalysis for Asymmetric Sulfide Oxidation” under the supervision of Prof. R. F. W. Jackson. This project was funded by the European Union and was part of an European Network project: COMBICAT “The Discovery of New Molecular Catalysts through Combinatorial Chemistry”. In December 2005, he moved to Milan where he undertook his experience at CISI scrl, originally a spin-off supported by the University of Milan on guidance of Prof. Carlo Scolastico, where he was involved on the “design, synthesis and biological screening of libraries of molecules obtained using high throughput techniques starting from original structural unities, for both diagnostic and therapeutic applications”. In March 2011, he moved to the Nanotechnologies Laboratory of the ISTM (CNR) in Milan, where he worked on a project concerning the Synthesis, design and characterization of SPIO nanoparticles conjugated to biomolecules for therapeutic and diagnostic applications under the supervision of Dr. Alessandro Ponti, with whom he currently continues to collaborate. Since November 2011, he is working as a permanent researcher (reg.-n° 14514) at the Institute of Biomolecular Chemistry (CNR) of Catania, where he is involved in research projects in the area of sustainable chemistry (development of catalytic, sustainable, for the transformation of used vegetable oils into biofuels), medicinal chemistry (synthesis of molecules for therapeutic and diagnostic applications) and in the field of functionalized materials both for the development of biosensors (amperometric, optical, etc.) and drug delivery (functionalization of SPIO nanoparticles).

Skills

Organic Synthesis


Heterogeneous Catalysis


Green Chemistry


Sustainable Processes


Biofuels


Enhancement of Renewable Feedstocks


Microwave Assisted Organic Synthesis

Publications

1. 1.    Zwitterion-Coated Iron Oxide Nanoparticles: Surface Chemistry and Intracellular Uptake by Hepatocarcinoma (HepG2) Cells; Sara  Mondini, Marianna  Leonzino, Carmelo  Drago, Anna  M.  Ferretti, Sandro  Usseglio, Daniela  Maggioni, Paolo  Tornese, Bice  Chini, Alessandro  Ponti, Langmuir, 2015, 31, 7381
   2.    Magnetic nanoparticles conjugated to chiral imidazolidinone as recoverable catalys; Sara Mondini, Alessandra Puglisi, Maurizio Benaglia, Daniela Ramella, Carmelo Drago, Anna M. Ferretti, and Alessandro Ponti, J Nanopart Res (2013) 15:2025
   3.    One-pot microwave assisted catalytic transformation of vegetable oil into glycerol-free Biodiesel; C. Drago, L. F. Liotta, V. La Parola, M. L. Testa and G. Nicolosi; Fuel, 2013, 113, 707
   4.    Bisphosphonate-functionalized cyclic Arg-Gly-Asp peptidomimetics; Carmelo Drago, Daniela Arosio, Cesare Casagrande, and Leonardo Manzoni; ARKIVOC 2013, 18
   5.    Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization; Pierfausto Seneci, Laura Belvisi, Martino Bolognesi, Monica Civera, Federica Cossu, Michelandrea De Cesare, Domenico Delia, Carmelo Drago, Daniele Lecis, Leonardo Manzoni, Eloise Mastrangelo, Mario Milani, Elisabetta Moroni, Paola Perego, Donatella Potenza, Vincenzo Rizzo, Cinzia Scavullo, Federica Servida, Francesca Vasile and Carlo Scolastico; Bioorganic & Medicinal Chemistry, 2012, 20, 6709
   6.     Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis; Pierfausto Seneci, Laura Belvisi, Aldo Bianchi, Martino Bolognesi, Carmelo Drago, Domenico Delia, Marilenia de Matteo, Luca Ferrante, Leonardo Manzoni, Paola Perego, Donatella Potenza, Vincenzo Rizzo, Federica Servida, Gabriele Timpano, Francesca Vasile and Carlo Scolastico; Bioorganic & Medicinal Chemistry, 2012, 20, 6687
   7.    Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib, D. Lecis, C. Drago, L. Manzoni, P. Seneci, C. Scolastico, E. Mastrangelo, M. Bolognesi, A. Anichini, H. Kashkar, H. Walczak and D. Delia, British Journal of Cancer, 2010, 102, 1707
   8.    Rational design, synthesis and characterization of potent, non-peptidic SMAC mimics/XIAP inhibitors as proapoptotic agent for cancer therapy, Pierfausto Seneci, Aldo Bianchi, Cristina Battaglia, Laura Belvisi, Martino Bolognesi, Andrea Caprini, Federica Cossu, Elena de Franco, Marilenia De Matteo, Domenico Delia, Carmelo Drago, Daniele Lecis, Leonardo Manzoni, Eloise Mastrangelo, Mario Milani, Ilaria Motto, Donatella Potenza, Vincenzo Rizzo, Federica Servida, Elisa Turlizzi, Maurizio Varrone, Francesca Vasile, and Carlo Scolastico, Bioorganic & Medicinal Chemistry, 2009, 17, 5834
   9.    Enantioselective oxidation of a alkyl aryl sulfide: Synthesis of (S)-(-)-Methyl p-bromophenyl sulfoxide, C. Drago, E. Walker, L. Caggiano and R.F.W. Jackson, Organic Syntheses, 2009, 86, 121. 
   10.    mimetics. Structure, activity and recognition principles, Eloise Mastrangelo, Federica Cossu, Mario Milani, Graziella Sorrentino, Daniele Lecis, Domenico Delia, Leonardo Manzoni, Carmelo Drago, Pierfausto Seneci, Carlo Scolastico, Vincenzo Rizzo and Martino Bolognesi, Journal of Biological Chemistry, 2008, 384, 673.
   11.    A Vanadium-catalysed Sulfur Oxidation/Kinetic Resolution Process for the Synthesis of Enantiomerically Pure Alkyl Aryl Sulfoxides, Carmelo Drago, Lorenzo Caggiano, and Richard F.W. Jackson, Angewandte-Chemie International Edition, accepted as VIP, 2005, 44, 7221

Contact

  RESEARCH SITE OF CATANIA

   carmelo.drago@cnr.it

  (+39) 095 7338350

Orcid: https://orcid.org/0000-0002-9924-179X

Scopus Author ID: 25626048900

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Dr. Nunzia Esercizio graduated in Biology in 2017 at the University of Naples Federico II with a score of 110/110 cum laude. In 2018-2019 she carried out a postgraduate internship at the Institute of Biomolecular Chemistry, ICB-CNR in Pozzuoli, under the supervision of Dr. Giuliana d’Ippolito and Prof. Angelo Fontana, taking an interest in the study of thermophilic bacteria for bio-hydrogen production and the optimization of fermentation culture parameters. In 2023 she obtained PhD in Biology at the University of Naples Federico II, presenting a thesis entitled “Characterization of the Capnophilic Lactic Fermentation pathway and molecular approaches in the hyperthermophilic bacterium Thermotoga neapolitana”. The research activity, which took place at the ICB-CNR Institute of Biomolecular Chemistry in Pozzuoli and under the supervision of prof. Angelo Fontana concerned the biochemical characterization of the CLF pathway in Thermotoga neapolitana, with the analysis of enzymes and metabolic flows. The study also concerned the gene manipulation of the strain and the optimization of production in selected conditions. In this regard, in 2019, the doctor was a guest at the Life Science department of Bowling Green University (Ohio, USA) under the supervision of Prof. Zhaohui Xu, to acquire the main genetic manipulation techniques applicable to thermophilic bacteria. In 2024, Dr. Nunzia Esercizio obtains a fixed-term researcher contract at the ICB in Pozzuoli as part of the H2 – AdC ENEA/CNR POR IDROGEN project, delving into the bioenergetic aspects of the bio hydrogen production pathways in Thermotogales, for the development of a microbial platform for technological exploitation with high yields and versatility of substrates use.

Skills

• Microbiology
• Fermentation
• Chemical Biology
• Molecular Biology

Publications

1_d’Ippolito G, Landi S, Esercizio N., Lanzilli M, Vastano M, Dipasquale L, Pradhan N and Fontana A. CO2-Induced Transcriptional Reorganization: Molecular Basis of Capnophillic Lactic Fermentation in Thermotoga neapolitana. Front. Microbiol. 2020. 11:171
2_Esercizio, N.; Lanzilli, M.; Vastano, M.; Landi, S.; Xu, Z.; Gallo, C.; Nuzzo, G.; Manzo, E.; Fontana, A.; d’Ippolito, G. Fermentation of Biodegradable Organic Waste by the Family Thermotogaceae. Resources. 2021, 10, 34.
3_Lanzilli, M.; Esercizio, N.; Vastano, M.; Xu, Z.; Nuzzo, G.; Gallo, C.; Manzo, E.; Fontana, A.; d’Ippolito, G. Effect of Cultivation Parameters on Fermentation and Hydrogen Production in the Phylum Thermotogae. Int. J. Mol. Sci. 2021, 22, 341.
4_Esercizio, N.; Lanzilli, M.; Vastano, M.; Xu, Z.; Landi, S.; Caso, L.; Gallo, C.; Nuzzo, G.; Manzo, E.; Fontana, A.; et al. Improvement of CO2 and Acetate Coupling into Lactic Acid by Genetic Manipulation of the hyperthermophilic Bacterium Thermotoga neapolitana. Microorganisms 2021, 9, 1688.
5_Esercizio, N.; Lanzilli, M.; Landi, S.; Caso, L.; Xu, Z.; Nuzzo, G.; Gallo, C.; Manzo, E.; Esposito, S.; Fontana, A.; et al. Occurrence of Capnophilic Lactic Fermentation in the Hyperthermophilic Anaerobic Bacterium Thermotoga sp. Strain RQ7. Int. J. Mol. Sci. 2022, 23, 1204

Contacts

  MAIN RESEARCH SITE, POZZUOLI (NA)

   nunzia.esercizio@cnr.it

   (+39) 0818675182

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From 1999 to present: Permanent position of Senior Researcher at the Institute for the Application of Advanced Chemical Techniques to Agro-biological Problems of Sassari later became Institute of Biomolecular Chemistry (UOS of Sassari).
Since 2007: Head of Unit’s Activities of the National Research Council: PM.P01.011.004 “Synthesis of multifunctional molecules with conformational rigidity for treatment of neurodegenerative diseases” within the Project: PM.P01.011 “Synthesis and molecular diversity of biologically active compounds of social importance”concerning the Project:”Molecular design of biochemical properties (pharmacological, biological and genetic aspects) “.
From 2006 to 2007: Head of Unit’s Activities of the National Research Council: PM.P01.011.004: “Ligands of nicotinic receptors that modulate neurotransmitters (nAChRs) “as part of the Project: PM.P01.011: “Chemical synthesis and diversity molecular of biologically active compounds” relating to the Project: “Molecular design of biochemical properties (pharmacological, biological and genetic aspects) “.
From 1994 to 1999 Researcher (ex art. 23, DPR 171/91) at the CNR Institute for the Application of Advanced Chemical Techniques to Agro-biological Problems of Sassari.
From 1989 to 1991 CNR biennal scholarship (Law 1 August 1988 No. 326) at the CNR Institute for the Application of Advanced Chemical Techniques to Agro-biological Problems of Sassari.
From 1989 to 1989 Scholarship “Federchimica-Zambon Group Spa” at the Department of Chemistry of the University of Sassari.

1989 State Examination. Authorization to practice the profession of Chemist.

Skills

Synthesis of natural and natural-like biphenols with antioxidant activity, dentification


Dentification


Design


Synthesis and characterization of biphenilic molecules as fungicides and inhibitors of trichothecene and tricodieneand preparation of the corresponding complexes with ß-cyclodextrin


Synthesis and characterization of biphenilic molecules as fungicides and inhibitors of trichothecene and tricodiene


synthesis and characterization of biphenilic molecules as fungicides and inhibitors of trichothecene and tricodiene

Chirality

Publications

Dettori, M.A.; Fabbri, D.; Pisano, M.; Rozzo, C. and Delogu, G. “Synthesis of Hydroxylated Biphenyls Derivatives Bearing an α,β-Unsaturated Ketone as Lead Structure for the Development of New Drug Candidates Against Malignant Melanoma” ChemMedChem 2021, 16, 1022-1033.

Oufensou.; Casalini, S.; Balmas, V.; Carta,. Chtioui, W.; Dettori M.A.; Fabbri, D.; Migheli, Q. and Delogu, G. “Prenylated trans-cinnamic esters and ethers against clinical Fusarium spp.: repositioning of natural compounds in antimicrobial discovery” Molecules 2021, 26, 658-675.

Kancheva, V.D.; Detttori, M.A.; Fabbri, D.; Alov, P.; Angelova, S.E.; Slavova-Kazakova, K.; Carta, P.; Menshov, V.A.; Yablonskaya, O.I.; Trofimov, A.V.; Tsakovska, I. Saso, L. “Natural Chain-Breaking Antioxidant and their Synthetic Analogs as Modulator of Oxidative Stress” Antioxidant 2021, 10, 624-652.

Brboric. J.; Klisic, A.; Kotur-Stevuljevic, J.; Delogu, G.; Gjorgieva Ackova, D.; Kostic, K.; Dettori, M.A.; Fabbri, D.; Carta, P.; Saso, L. “Natural and Natural-like Polyphenol Compounds: in Vitro Antioxidant Activity and Potential for Therapeutic Application” Archives of Medical Science, 2021, in press

Pisano, M.; Dettori, M.A.; Fabbri, D.; Delogu, G.; Palmieri, G. and Rozzo, C. “Anticancer activity of two Novel Hydroxylated Biphenyl Compound toword Malignant Melanoma Cells” Int. J. Mol. Sci. 2021, 22, 5636.

Contacts

   RESEARCH SITE OF SASSARI

   davidegaetano.fabbri@cnr.it

   (+39) 079 2841223 – Cell: 3339910778

ORCID: 0000-0002-4075-4793

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   RESEARCH SITE OF SASSARI

    emma.fenude@cnr.it

   (+39) 079 2841205

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  RESEARCH SITE OF CATANIA

  loredana.ferreri@cnr.it

   095 7338338

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Tiziana Ferreri graduated in Industrial Chemistry (grade, 110/110 cum laude) at the University of Catania, Italy, supporting an experimental thesis entitled “Photoxidation products of Ultem polyether imide”. She worked as quality assurance manager and head of the Chemical/Biological laboratory at Medical System srl, in charge to the Quality System and organizing/supervision the chemical-biological tests on biomedical devices. She performed her internship at Sviluppo Chimica S.p.A. where she was involved on the management of Venture Capital projects in Sicily, where she drew up the Business Plans and an economic and scientific development plan for Sicily. On behalf of the Province of Caltanissetta, She also drew up the executive project to launch of an Environmental and Agri-food Analysis Laboratory. She worked at the Institute for Composite and Biomaterial Polymers of the CNR in Catania, where she was involved in the planning, drafting and development of research projects at regional, national and international levels. Among the activities supporting the research, she has been involved in the development of polymeric systems with antimicrobial activity for both biomedical and food packaging sectors. Since October 2019 she is a Technologist of the National Research Council working at the Institute of Biomolecular Chemistry, branch of Catania.

Skills

Design


Technology transfer


Training


Antimicrobial materials

Publications

Zampino, D., Mancuso, M., Zaccone, R., Recca, G., Puglisi, C., Thermo-mechanical, antimicrobial and biocompatible properties of PVC blends based on imidazolium ionic liquids. Materials Science and Engineering C, (2021), 122, 111920.

https://doi.org/10.1016/j.msec.2021.111920

Calabrese V., Dattilo S., Petralia A., Pennisi M., Koverech G., Koverech A., Graziano A., Fronte V., Ferreri T., Calabrese E. J., Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics. Free Radical Research, (2015) 49(5), 511–524.

https://doi.org/10.3109/10715762.2015.1020799

E. Lallana, T. Ferreri, S. Carroccio, A. Puga, N. Tirelli “End-group rearrangements in poly(propylene sulfide) MALDI-TOF analysis. Experimental evidences and possible mechanisms”. Rapid Communications in Mass Spectrometry (2012), 26, 2158-2164.

https://doi.org/10.1002/rcm.6337

Zampino D., Ferreri T., Concetto P., Mancuso M., Zaccone R., Scaffaro R., Bennardo D. (2011) – PVC silver zeolite composites with antimicrobial properties. Journal of Materials Science, (2011), 46, 6734-6743.

https://doi.org/10.1007/s10853-011-5629-y

Sabrina Carroccio, Concetto Puglisi, Giuseppina Scaltro, Tiziana Ferreri, Giorgio Montaudo – 2007 “Matrix-assisted laser desorption/ionization time-of-flight investigation of Nylon 6 and Nylon 66 thermo-oxidation products” European Mass Spectrometry Journal, (2007) 13(6), 397-408.

https://doi.org/10.1255/ejms.899

Contacts

  RESEARCH SITE OF CATANIA

  PEC: tiziana.ferreri@pec.chimici.it

   tiziana.ferreri@cnr.it

   (+39) 095 7338353

ORCID: https://orcid.org/0000-0002-4051-4191

Researcher ID: AAZ-1052-2021

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Dr. Finore received his Bachelor Degree in Environmental Sciences, Marine specialization at the Parthenope University in 2006, discussing the experimental thesis in Marine Microbiology entitled “Biodiversity studies of halophilic species of the salt lake Fuente de Piedra” , with the vote of 110/110; She then obtained the title of Expert in the Management of Protected Natural Areas at the University of Molise, from the 1st Master (Level II) in Governance of protected natural areas. In 2011, Dr. Finore obtained the title of DOCTOR of RESEARCH in “Environment, Resources and Sustainable Development” (XXIII cycle) by discussing the experimental doctoral thesis entitled: “Bioethanol: a source of renewable energy from extremophiles” with Label of “Doctor Europaeus” held at the CNR Institute of Biomolecular Chemistry of Pozzuoli (Na). Since 2019, she was promoted to the position of research fellow at ICB for the strategic area of ​​Green Chemistry.

Skills Extremophilic microorganisms
Extremozymes
Exopolysaccharides
Biotransformation
Waste biomass valorization. Publications

• Finore Ilaria; Adrien Vigneron; Warwick F. Vincent; Luigi Leone; Paola Di Donato; Aniello Schiano Moriello; Barbara Nicolaus; Annarita Poli (2020) “Novel Psychrophiles and Exopolymers fromPermafrost Thaw Lake Sediments”Microorganisms, 8, 1282.
  https://pubmed.ncbi.nlm.nih.gov/32842646/

• Ilaria Finore, Licia Lama, Paola Di Donato, Ida Romano, Annabella Tramice, Luigi Leone, Barbara Nicolaus, Annarita Poli (2019) Parageobacillus thermantarcticus, an Antarctic Cell Factory: From Crop Residue Valorization by Green Chemistry to Astrobiology Studies Diversity 11(8), 128; https://doi.org/10.3390/d11080128

• Di Donato Paola, Finore Ilaria, Poli Annarita, Nicolaus Barbara, Lama Licia (2019) “The production of second generation bioethanol: The biotechnology potential of thermophilic bacteria”. J of Cleaner Production 233; 1410-1417 DOI: 10.1016/j.jclepro.2019.06.152

• Ilaria Finore, Annarita Poli, Paola Di Donato, Licia Lama, Antonio Trincone, Massimo Fagnano, Mauro Mori, Barbara Nicolaus and Annabella Tramice ‘The hemicellulose extract from Cynara cardunculus: a source of value-added biomolecules produced by xylanolytic thermozymes’ Green Chem., 2016,18, 2460-2472 DOI: 10.1039/C5GC02774H

• Faruk Küçükaşik, Hande Kazak, Dilvin Güney, Ilaria Finore, Annarita Poli, Orhan Yenigün, Barbara Nicolaus, Ebru Toksoy Öner (2011). ‘Molasses as Fermentation Substrate for Levan production by Halomonas sp.’ Appl Microbiol Biotechnol (2011) DOI 10.1007/s00253-010-3055-8

Contacts   MAIN RESEARCH SITE, POZZUOLI (NA)

   ilaria.finore@icb.cnr.it

   PEC: ilariafinore@pec.it

   (+39) 081 8675118

ORCID: orcid.org/0000-0003-3606-5140;
Researcher Scopus ID: 18036971400;
Web of Science Researcher ID: P-9423-2018 Publons Web of science Scholar View curriculum MDPI

ICB Director

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Director of the Institute of Biomolecular Chemistry

Biography Skills Publications Contact Biography

Full Professor of Organic Chemistry at the University of Naples “Federico II” (ORCID N. 0000-0002-5453-461X; WOS Researcher ID C-3354-2012), with a strong dedication to chemical biology and interdisciplinary research. Scientific work focuses on small, naturally derived molecules with pharmaceutical relevance, particularly in the areas of immunology and oncology, and on their application as tools to explore and modulate complex biological systems. Research activities include the discovery and characterization of bioactive compounds from marine organisms, investigation of their biosynthetic pathways and regulatory mechanisms, and the design of molecules that interact with cellular targets to influence key biological processes. A translational research approach is adopted, bridging basic science with medical and biotechnological applications, through the integration of organic chemistry, chemical biology, and advanced analytical technologies.

Main Research Areas:

• Discovery of novel antitumor and immunomodulatory compounds through chemical biology
• Isolation, structural elucidation, and synthesis of natural products
• Study of biosynthetic pathways and secondary metabolism
• Mechanisms of action and chemical communication mediated by lipids and small molecules

Technologies and Additional Interests

Research activities rely on advanced analytical techniques such as mass spectrometry (MS), nuclear magnetic resonance (NMR), and cytometry. There is also a strong interest in technological approaches for elucidating biosynthesis and the cellular function of natural products.

Skills

 analysis, isolation, structural characterization and chemical synthesis of small organic molecules and their use in cell biology

 Biosynthesis of natural products and chemical studies of metabolism and cellular processes

 Functional applications and chemical biology of lipids and secondary metabolites

 Chemical communication mediated by small molecules

 Identification and mechanism of action of bioactive compounds

 Drug discovery and proof-of-concept of new pharmaceutical compounds (in particular antitumor and immunomodulating compounds)

 Implementation of biotechnological processes and functional products

 Chromatography

 Spectroscopy

 Synthesis

 NMR and MS

 Synthetic biology

Publications

in aggiornamento…

Contact

   MAIN RESEARCH SITE, POZZUOLI (NA)

   direttore.icb@cnr.it

   (+39) 081 8675018 – 081 8661444

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ICB Director

Researchers and technologists

Technical and administrative

Biography Skills Publications Contacts Biography

Doctor Mario Concetto Foti was born in Mascali (CT) on 8 December 1961, he graduated cum laude in pure chemistry in 1988 at the University of Catania, and in 1995 he was awarded the title of PhD by the Federico II University of Naples. From January 1999 he started working as a researcher of the Italian CNR and later has started developing kinetic models for antioxidants. From 1992 to 1994, he worked at the “National Research Council” (Ottawa, Canada), in the laboratory of Dr. Keith U. Ingold, distinguished scientist of the NRC. Later (2000 – 2001) he worked as “Research Associate” at the laboratory of Prof. Ross Barclay of the Mount Allison University of Sackville, New Brunswick, Canada, where he worked on naphthalen-1,8-di-olic antioxidants. In the academic years 2010 to 2012 he was appointed adjunct professor at the Faculty of Pharmacy teaching “Principles of General Chemistry” to students of Herbal Sciences and Nutraceuticals.

Skills

Chemistry of radicals


Antioxidant


Dpph


Mechanisms of reaction


HAT


SPLET


ET


Solvent effects


phenols


Chemical kinetics

Publications

1) Mario C. Foti, Carmelo Daquino, Corrada Geraci, Electron-Transfer Reaction of Cinnamic Acids and Their Methyl Esters with the DPPH• Radical in Alcoholic Solutions

J. Org. Chem. 2004, 69 (7), 2309-2314

Citato 691 volte (Google Scholar).

 

2) Riccardo Amorati, Mario C. Foti, Luca Valgimigli, Antioxidant activity of essential oils

J. Agric. Food Chem. 2013, 61 (46), 10835-10847

Citato 532 volte (Google Scholar).

 

3) Mario Foti, Mario Piattelli, MT Baratta, Giuseppe Ruberto, Flavonoids, coumarins, and cinnamic acids as antioxidants in a micellar system. Structure− activity relationship

J. Agric. Food Chem. 1996, 44 (2), 497-501

Citato 479 volte (Google Scholar).

 

4) Mario C. Foti, Antioxidant properties of phenols (review)

J. Pharm. Pharmacol. 2007, 59 (12), 1673-1685

Citato 263 volte (Google Scholar)

 

5) Mario C. Foti, Use and Abuse of the DPPH• Radical (review)

J. Agric. Food Chem. 2015, 63 (40), 8765-8776

Citato 195 volte (Google Scholar)

Contacts

  RESEARCH SITE OF CATANIA

  marioconcetto.foti@cnr.it

  (+39) 095 7338343

ORCID: https://orcid.org/0000-0003-1218-4612

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ICB Director

Researchers and technologists

Technical and administrative