A significant population of COVID-19 patients subsequently experiences many months after acute infection lasting muscle weakness and exercise intolerance as the most common symptoms. Emerging evidence suggests that in this condition, commonly referred to as post-acute sequelae of SARS-CoV-2 infection but also known as post-COVID-19 condition or Long-COVID (LC), prolonged symptom duration and limitations in functioning are common among hospitalized as well as non-hospitalized adults thus becoming a significant global health burden.
Mechanisms underlying muscle weakness and exercise intolerance are not yet understood strongly limiting the development of intervention strategies for LC.
Our project tackles mechanisms of LC symptoms by taking advantage of a scientific team covering a broad range of expertise, from molecular to integrative and clinical expertise.
The purpose of this study is to provide mechanistic insights into muscle weakness and exercise (in)tolerance in LC patients.
Project objective:
The purpose of this study is to provide mechanistic insights into muscle weakness and exercise (in)tolerance in LC patients. We will test the hypothesis that an exaggerated immune response may be abnormally protracted in patients after virological recovery leading to a state of persistent inflammation that may drive muscle wasting, muscle weakness and exercise intolerance symptoms
Coordinator and involved ICB staff:
Lead institution:
Università degli Studi di PAVIA
Lead institution:
ICB-CNR
