Researchers and technologists

Biography Skills Publications Contacts Biography

Milena Casula is a researcher of the Institute of Biomolecular Chemistry (ICB) CNR, and she collaborates with the Institute for Genetic and Biomedical Research, CNR. She received her Academic Degree in Biological Science at the University of Sassari in 1999 and her PhD Degree in Biochemistry, Biology and Molecular Biotechnology at the University of Sassari in 2008. She has extensive background in biological sciences combined with a strong practical work experience in basic research, mainly focused on oncology studies. She worked abroad at the Doctor Negrin University Hospital of Gran Canaria studying the role of Wnt/beta-catenin and Toll Like Receptors Signaling Pathways in the acute lung injury and acute respiratory distress syndrome, testing new biological molecules on cell culture model for sepsis-related processes. She is the author of several scientific articles (Web of Science H-index: 20) and she is currently involved in the analysis of circulating tumor DNA (ctDNA) using highly sensitive methods such as Next Generation Sequencing and Droplet Digital PCR.

Skills Molecular oncology Immunohistochemistry (IHC) Immunocytochemistry (ICC) WesternBlottin Next Generation Sequencing technology (IonTorrent, Illumina) Manually designing of targeted NGS panels Realtime PCR Droplet Digital™ PCR (ddPCR™) Publications

1. Calabrò L, Rossi G, Morra A, Rosati C, Cutaia O, Daffinà MG, Altomonte M, Di Giacomo AM, Casula M, Fazio C, Palmieri G, Giannarelli D, Covre A, Maio M. Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT-MESO-1 study. Lancet Respir Med. 2021 Sep;9(9):969-976. doi: 10.1016/S2213-2600(21)00043-6. Epub 2021 Apr 9. PMID: 33844995.

2. Ottaviano M, Giunta EF, Rescigno P, Pereira Mestre R, Marandino L, Tortora M, Riccio V, Parola S, Casula M, Paliogiannis P, Cossu A, Vogl UM, Bosso D, Rosanova M, Mazzola B, Daniele B, Palmieri G, Palmieri G. The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something? Int J Mol Sci. 2021 Jul 2;22(13):7160. doi: 10.3390/ijms22137160. PMID: 34281219; PMCID: PMC8267694.
3. Palmieri G, Rozzo CM, Colombino M, Casula M, Sini MC, Manca A, Pisano M, Doneddu V, Paliogiannis P, Cossu A. Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy? Front Oncol. 2021 May 5; 11:666624. doi: 10.3389/fonc.2021.666624. PMID: 34026645; PMCID: PMC8132875.
4. Vanni I, Casula M, Pastorino L, Manca A, Dalmasso B, Andreotti V, Pisano M, Colombino M; Italian Association for Cancer Research (AIRC) Study Group, Pfeffer U, Tanda ET, Rozzo C, Paliogiannis P, Cossu A, Ghiorzo P, Palmieri G; Italian Melanoma Intergroup (IMI). Quality assessment of a clinical next-generation sequencing melanoma panel within the Italian Melanoma Intergroup (IMI). Diagn Pathol. 2020 Dec 14;15(1):143. doi: 10.1186/s13000-020-01052-5. PMID: 33317587; PMCID: PMC7737361.

5. Casula M, Paliogiannis P, Ayala F, De Giorgi V, Stanganelli I, Mandalà M, Colombino M, Manca A, Sini MC, Caracò C, Ascierto PA, Satta RR; Melanoma Unit of Sassari (MUS), Lissia A, Cossu A, Palmieri G; Italian Melanoma Intergroup (IMI). Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study. BMC Cancer. 2019 Aug 5;19(1):772. doi: 10.1186/s12885-019-5984-7. PMID: 31382929; PMCID: PMC6683413.

Contacts   RESEARCH SITE OF SASSARI    milena.casula@cnr.it – casulam@yahoo.it    PEC: casulam@pec.it   Cell (+39) 3421596475 Skype ID: milena. casula73 ORCID: https://orcid.org/0000-0002-5079-9864 Web of Science Researcher ID: AAA-7461-2019 Scopus Author ID: 7003794527 View curriculum

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Paola Carta was born in Sassari on October 18, 1972. She graduated with honors in Chemistry and Pharmaceutical Technologies (CTF) in 1996 at the University of Sassari. From 1997 to 2000 she worked as a researcher at the CNR Institute for the Application of Advanced Chemical Techniques to Agrobiological Problems in Sassari. In 2005 she obtained her PhD in Organic Chemistry at King’s College London and in 2004 she participated as Visiting PhD student at the Institute of Organ-Element Compounds at the Russian Academy of Sciences, Moscow. From 2005 to 2006 she carries out research work as postdoc at the Universitè Pierre et Marie Curie in Paris. She returned to Italy in 2006 and until 2018 she worked as researcher at ICB UOS Sassari, Porto Conte Ricerche srl (Alghero, SS) and for the NeED Pharmaceuticals s.r.l. Since 2018 she holds a permanent researcher position (III level) at the Institute of Biomolecular Chemistry UOS-Sassari.

Main Interests:

• Design, synthesis and study of multifunctional hydroxylated biphenyl derivatives of natural origin.

• Organic synthesis of natural and natural-like small molecules with potential biological/pharmacological activity and analogues of natural products.

• Study, extraction and characterization of active ingredients from biomass through environmentally sustainable methods.

Skills

Synthetic Organic Chemistry


Natural Compounds


Hydroxylated Biphenyls


C2 symmetry


Green chemistry

Publications

• Prenylated Trans-Cinnamic Esters and Ethers against Clinical Fusarium spp.: Repositioning of Natural Compounds in Antimicrobial Discovery.

Safa Oufensou, Stefano Casalini, Virgilio Balmas, Paola Carta, Wiem Chtioui, Maria A. Dettori, Davide Fabbri, Quirico Migheli and Giovanna Delogu. Molecules 2021, 26, 658. 

• Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress.

Kancheva, V.D.; Dettori, M.A.; Fabbri, D.; Alov, P.; Angelova, S.E.; Slavova-Kazakova, A.; Carta, P.; Menshov, V.A.; Yablonskaya, O.I.; Trofimov, A.V.; Tsakovska, I.; Saso, L. Antioxidants 2021, 10, 624.

• Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes.

Dettori, M.A.; Fabbri, D.; Dessì, A.; Dallocchio, R.; Carta, P.; Honisch, C.; Ruzza, P.; Farina, D.; Migheli, R.; Serra, P.A.; Pantaleoni, R.A.; Fois, X.; Rocchitta, G.; Delogu, G.  Molecules 2020, 25, 2709.

• Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance.

Oufensou, S.; Scherm, B.; Pani, G.; Balmas, V.; Fabbri, D.; Dettori, M.A.; Carta, P.; Malbrán, I.; Migheli, Q.; Delogu, G.

PLoS ONE 2019, 14(9), e0221249. Synthesis of Magnolol and Honokiol Derivates and their Effect against Hepatocarcinoma cells.

Margherita Maioli; Valentina Basoli; Paola Carta; Davide Fabbri; Maria Antonietta Dettori; Sara Cruciani; Pier Andrea Serra; Giovanna Delogu.  PLoS ONE, 2018, 1-21. 

Contacts

  RESEARCH SITE OF SASSARI

   paola.carta@cnr.it

   (+39) 079 2841119

ORCID: 0000-0001-8749-6093

Web of Science ResearcherID: H-2026-2013

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Fabrizio Chiodo studies carbohydrate-mediated immunological responses mostly in the context of conjugate-vaccines and host-pathogen interactions. He defended his PhD in 2013 in Spain (Applied Chemistry, working on synthetic vaccines and nanotechnology applied to vaccinology), and in 2014 he obtained a personal grant from the Netherlands Organization for Scientific Research working at the Leiden Institute of Chemistry and Leiden University Medical Center. He initiated and strengthened International collaborations in the field of vaccinology especially with the Finlay Institute in Havana (Cuba), where he is appointed as Invited Lecturer at the Faculty of Chemistry. In 2018 he was awarded with a personal grant from the Amsterdam Infection and Immunity Institute working independently at the Y. van Kooyk group. From October 2020 he is a Research Assistant Professor at the Italian National Research Council (CNR) working at the Institute of Biomolecular Chemistry, Naples, keeping his affiliation and position also in Amsterdam.

Competenze

GlycoScience


GlycoImmunology


Carbohydrate-mediated interactions


Conjugate-vaccines


Innate responses

Pubblicazioni

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies. Y. Valdes-Balbin, D.Santana-Mederos, L. Quintero, S. Fernandez, L. Rodriguez, B. Sanchez-Ramirez, R. Perez, […], F. Chiodo, F. Paquet, G. Chen, D. G Rivera, D. Garcia-Rivera, V. Verez-Bencomo. 2021, ACS Chemical Biology, 16, 7, 1223–1233

Q. Zhu, Z. Shen, F. Chiodo, S. Nicolardi, A. Molinaro, A. Silipo, B. Yu. Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus. 2020, Nature Communications, 11, 4142

Q. Zhang, A. Gimeno, D. Santana, Z. Wang, Y. Valdes-Balbin, L. Rodriguez-Noda, T. Hansen, L. Kong, M. Shen, H. Overkleeft, V. Verez-Bencomo, G. van der Marel, J. Jiménez-Barbero, F. Chiodo, J. Codée. Synthetic, zwitterionic Sp1-oligosaccharides adopt a helical structure crucial for antibody interaction. 2019, ACS Central Science, 5, 1407-1416

S. Nicolardi, Y. van der Burgt, M. Wuhrer, J. Codee. C. H. Hokke, F. Chiodo. Structural characterization of bio-functionalized gold nanoparticles by ultrahigh resolution mass spectrometry. 2017, ACS Nano, 11, 8257-8264

M. Marradi, F. Chiodo, I. García, S. Penadés. Glyconanoparticles as multifunctional and multimodal carbohydrate systems. 2013, Chemical Society Reviews, 42, 4728-4745

Contatti

   MAIN RESEARCH SITE, POZZUOLI (NA)

   fabrizio.chiodo@cnr.it

   f.chiodo@amsterdamumc.nl

ORCID: https://orcid.org/0000-0003-3619-9982

Web of science Scholar View curriculum

Direttore ICB

Ricercatori e tecnologi

Tecnici e amministrativi

Biography Skills Publications Contact Biography Skills Publications Contact

  MAIN RESEARCH SITE, POZZUOLI (NA)

  marialetizia.ciavatta@cnr.it

  (+39) 081 8675243

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Dr. MariaColombinograduated in Molecular Biology and obtained the PhD in Biochemistry, Biology and Molecular Biotechnology at the University of Sassari, Italy. She worked as Visiting Postdoctoral Fellow at the Laboratory of Genetics at the National Institute on Aging (NIA) of the National Institutes of Health (NIH). She is Research’sCNR (National Research Council) of the Institute of Biomolecular Chemistry (ICB)butactually she is affiliateof the Sassari Branch ofthe Institute of Genetic and Biomedical Research (IRGB). Her research activity is correlate to the identification and characterization of somatic and germline alterations in candidate genes involved in susceptibility to neoplasm and/or in tumorigenesis with particular focus in Malignant Melanoma and Non Small Cell Lung Cancer. Dr. Colombinois author of more than 42peer-reviewed publications (Scopus H-index: 20, WoS H-index: 19) and several book chapters. She has been invited as Speakerin more than 10Congresses in past ten years

Skills

Cancer Biomarker


Cancer genetic

Melanom


Molecular Biology


Translational Medicine


Next Generation Sequencing


Real Time PCR


Pyrosequencing

Publications

Genetic Instability Markers in Cancer. Palmieri G, Casula M, Manca A, Palomba G, Sini MC, Doneddu V, Cossu A, Colombino M.Methods Mol Biol. 2020;2055:133-154. doi: 10.1007/978-1-4939-9773-2_6. PMID: 31502150 

Comparison of BRAF Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients. Colombino M, Rozzo C, Paliogiannis P, Casula M, Manca A, Doneddu V, Fedeli MA, Sini MC, Palomba G, Pisano M, Ascierto PA, Caracò C, Lissia A, Cossu A, Palmieri G. J Clin Med. 2020 Jul 30;9(8):2430. doi: 10.3390/jcm9082430. PMID: 32751423

EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma.Colombino M, Paliogiannis P, Cossu A, Santeufemia DA; Sardinian Lung Cancer (SLC) Study Group, Sini MC, Casula M, Palomba G, Manca A, Pisano M, Doneddu V, Palmieri G. BMC Pulm Med. 2019 Nov 11;19(1):209. doi: 10.1186/s12890-019-0964-x. PMID: 31711449

Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches. Palmieri G, Colombino M, Casula M, Manca A, Mandalà M, Cossu A; Italian Melanoma Intergroup (IMI). Curr Oncol Rep. 2018 Sep 14;20(11):86. doi: 10.1007/s11912-018-0733-7. PMID: 30218391

BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. Colombino M, Capone M, Lissia A, Cossu A, Rubino C, De Giorgi V, Massi D, Fonsatti E, StaibanoS, Nappi O, Pagani E, Casula M, Manca A, Sini M, Franco R, Botti G, Caracò C, Mozzillo N, Ascierto PA, Palmieri G. J Clin Oncol. 2012 Jul 10;30(20):2522-9.doi: 10.1200/JCO.2011.41.2452. PMID: 22614978

Contacts

  RESEARCH SITE OF SASSARI

   maria.colombino@cnr.it – colombinom@yahoo.it

  PEC: colombinom@pec.it

Scopus Author Identifier: 6602522509

Orcid: https://orcid.org/0000-0001-8051-3356

Web of Science ResearcherID: AAX-7371-2020

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Grazia Maria Letizia Consoli graduated in Biological Sciences at the University of Catania in 1989 with 110 cum laude. He holds a Specialization in Biochemistry and Clinical Chemistry at the University of Catania. He has carried out research activities at the Institute for the Study of Natural Substances of Food and Chemical-Pharmaceutical Interest (scholarships funded by MIUR). Since 1999 she has been a researcher at the CNR Institute of Biomolecular Chemistry. In 2004 she was visiting researcher at the University of Konstanz (Germany). He deals with organic synthesis, structural characterization and supramolecular chemistry aimed at drug discovery and drug delivery.

Skills Organic synthesis
Structural characterization
Supramolecular chemistry
Host-guest chemistry
Multivalent compounds
Nanostructured systems
Drug discovery
Drug delivery
Antimicrobials
Anticancers Publications Contacts

  RESEARCH SITE OF CATANIA

   graziamarialetizia.consoli@cnr.it

  (+39) 095 7338319

ORCID: http://orcid.org/0000-0002-9608-5138

Researcher ID: AAY-9836-2021

Scopus Webofscience Scholar View curriculum

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Luigia Cristino is Senior Researcher at ICB-CNR. She coordinates the research group “Neurochemistry and Cell Signaling” for studies in “Chemistry for Health” and biological evaluation of the effects of small bioactive organic molecules, natural or synthetic, by exploiting time-lapse integrated microscopy techniques (cell imaging and patch-clamp registration) and the IncuCyte® platform for preclinical research in medicinal chemistry applied to neuroscience and immunology.
Her research is focused on the study of chemical communication between cells and identification of molecular pathways of signal transduction at GCPRs receptors (mainly in particular (endo)cannabinoids, (endo)vanilloids, orexin, SCFAs and endocannabinoid-like metabolites produced by gut microbiota) with metabolic, morphological and functional effect on synaptic homeostasis and microbiota-gut-brain axis, in physiological or neuroinflammatory states (mainly obesity and aging), in mouse and cellular models. For research activity she has received funding from national and international research agencies (MIUR: PRIN_PNRR2022 “NeuroFood”; PON «R&I»ARS01_01270 IDF SHARID; PRIN2017 # 2017M42834_002; HORIZON 2020/Marie Curie Action INCIPIT; Canada Sentinelle Nord; Plantex; GW and Jazz Pharma).

Skills

Drug and food addiction


Orexin/hypocretin

hypothalamus

Cannabinoids

Cell signal trasduction

Immuno-cytochemistry

Immuno-histochemistry

Confocal and Electron Microscopy

Time lapese cell imaging

Elettrophysiology

Publications

1. “Cannabinoids and the expanded endocannabinoid system in neurological disorders” Cristino L, Bisogno T, Di Marzo V. NATURE REVIEW NEUROLOGY, 2020. 16:9-29. DOI: 10.1038/s41582-019-0284-z.

2. “Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice”. Forte N, Boccella S, Tunisi L, Fernández-Rilo AC, Imperatore R, Iannotti FA, De Risi M, Iannotta M, Piscitelli F, Capasso R, De Girolamo P, De Leonibus E, Maione S, Di Marzo V, Cristino L. NATURE COMMUNICATIONS. 2021;12:6137. DOI: 10.1038/s41467-021-26388-4.

3. “Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity”. Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L.
MOLECULAR METABOLISM. 2023;72:101713. DOI: 10.1016/j.molmet.2023.101713.

4. “Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling”. Morello G, Imperatore R, Palomba L, Finelli C, Labruna G, Pasanisi F, Sacchetti L, Buono L, Piscitelli F, Orlando P, Di Marzo V, Cristino L. PNAS 2016; 26,113:4759-64. DOI: 10.1073/pnas.1521304113.

5. “Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons”. Cristino L, Busetto G, Imperatore R, Ferrandino I, Palomba L, Silvestri C, Petrosino S, Orlando P, Bentivoglio M, Mackie K, Di Marzo V.
PNAS 2013; 110:E2229-38. DOI: 10.1073/pnas.1219485110.

Contact

    Main office in Pozzuoli (NA)

  luigia.cristino@cnr.it

   (+39) 081 8675134

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  RESEARCH SITE OF SASSARI

  nicola.culeddu@cnr.it

  (+39) 079 2841211

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Biography Skills Publications Contacts Biography

In 1983 she graduated in Chemistry cum laude from the University of Catania discussing a thesis entitled: “Oxoalgerienol and oxoalgeriendiol: two new metabolites from the brown alga Cystoseira Algeriensis”.

From September 1986 to November 1988 she had two scholarships from the CNR and in December 1988 she started as a permanent researcher at the ISSN-CNR in Catania.

In the period August 2001-April 2002, thanks to the short term mobility program and CNR-NATO Senior Grant, she attended the chemistry laboratory directed by Prof. AD Hamilton at Yale University, collaborating on the synthesis of new surface receptors for biomacromolecules.

The activity, started in the field of natural molecules with the isolation and structural characterization of secondary metabolites, turned to the study and possible applications in the bioorganic field of supramolecular chemistry, with particular attention to the synthesis and conformational pre-organization of calixarene macrocycles.

She has been involved in many research projects and has carried out several teaching and tutoring activities.

Now she is currently involved in the design and synthesis of macroporous polymeric materials and their applications in the biomedical and environmental fields.

Skills

Supramolecular Chemistry


Calixarenes


Molecular Recognition


Polyelectrolites


Hydrogel


Macroporous polymers


Cryogel

Publications

1) T. Mecca et al. N-methyl-D-glucamine based cryogels as reusable sponges to enhance heavy metals removal from water; Chemical Engineering Journal 399, 125753 (2020)

2) M. Ussia et al. ZnO–pHEMA Nanocomposites: An Ecofriendly and Reusable Material for Water Remediation; ACS Appl. Mater. Interfaces, 10, 46, 40100 (2018)

3) G. Granata et al. Potential Eye Drop Based on a Calix[4]arene Nanoassembly for Curcumin Delivery: Enhanced Drug Solubility, Stability, and Anti-Inflammatory Effect; Mol. Pharmaceutics, 14, 1610 (2017)

4) R. La Spina et al. Chemically modified poly(2-hydroxyethyl methacrylate) cryogel for the adsorption of heparin; J. Biomed. Mater. Res. Part B, 102, 1207 (2014)

5) T. Mecca et al. Novel pH responsive calix[8]arene hydrogelators: self-organization processes at a nanometric scale; Chem. Commun., 49, 2530 (2013)

Contacts

   RESEARCH SITE OF CATANIA

  francesca.cunsolo@cnr.it

   (+39) 095 7338333 – Cell: (+39) 3478071418


ORCID:
https://orcid.org/0000-0002-6766-8174

Scopus Author ID: 6602806308

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ICB Director

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Head of the research site of Catania

Biography Skills Publications Contacts Biography

He graduated in Chemistry (Organic-Biologic specialization) at the University of Catania in 1997. Since 1997 to 2007 he has worked as postdoc at the ISSN-CNR, lately known as ICB-CNR. In 2004 he was Visiting Researcher at the “Institut für Bioverfahrenstechnik” – University of Stuttgart, Germany – in the group of Prof. C. Syldatk. Since 2008 he is researcher at Istituto di Chimica Biomolecolare of Consiglio Nazionale delle Ricerche (ICB-CNR), and since 2017 he is Head of Catania branch of ICB-CNR.

His scientific activity has been according to some macro topics characterized by an high grade of multidisciplinarity and more specifically focused on:

• Chemistry of natural compounds.

• Enzymatic biocatalysis and organometallic catalysis.

• Organic “green” synthesis.

• Valorization of biomasses.

Skills Biocatalysis
Organic synthesis
Chiral resolution
Lipases
Nitrilases
Green chemistry
Valorisation of waste biomasses
Sustainable Processes Publications

1. Di Mauro M.D.; Fava G.; Spampinato M.; Aleo D.; Melilli B.; Saita M.G.; Centonze G.; Maggiore R.; D’Antona N. Polyphenolic Fraction from Olive Mill Wastewater: Scale-Up and in Vitro Studies for Ophthalmic Nutraceutical Applications. Antioxidants (2019), 8(10), 462; https://doi.org/10.3390/antiox8100462.

2. Colombo, A.; Schievano, A.; Trasatti, S.P.; Morrone, R.; D’Antona, N.; Cristiani, P. “Signal trends of microbial fuel cells fed with different food-industry residues.” Int. J. Hydrogen Energy 2017, 42, 1841-1852.

3. D’Antona, N.; Morrone, R.; Gambera, G.; Pedotti, S. “Enantiorecognition of planar “metallocenic” chirality by a nitrile hydratase/amidase bienzymatic system.” Org. Biomol. Chem. 2016, 14, 4393-4399.

4. D’Antona, N.; Morrone, R.; Nicolosi, G.; Pedotti, S. Novel enzymatic recognition of the ferrocene framework: nitrile hydratase/amidase catalyzed cascade biotransformations. RSC Adv (2013), 3, 11456-11458.

5. Morrone, R.; D’Antona, N.; Biondi, D.; Lambusta, D.; Nicolosi, G. “Preparation of n3-PUFAs ethyl esters by an efficient biocatalyzed solvent-free process.” Journal of Molecular Catalysis B: Enzymatic 2012, 84, 173-176.

Contacts

  RESEARCH SITE OF SASSARI

  nicola.dantona@cnr.it

  PEC: nicola.dantona@pec.it

   (+39) 095 7338342

Orcid: https://orcid.org/0000-0002-1711-8262

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Adele Cutignano graduated summa cum laude in 1993 in Pharmaceutical Chemistry, University of Naples Federico II, where she also obtained her PhD in Agricultural Chemistry in 1997; in 1999 she got the Specialization in Hospital Pharmacy at University of Salerno with highest marks and honors. From 1997 to 2001 she obtained Post-doc and Research Assistant positions at University of Salerno. In 2001 she obtained a permanent position as Researcher at CNR- ICB where she currently is Senior Researcher since 2020.

Skills

  Natural product chemistry

  Drug discovery

 Secondary metabolites biosynthesis

  Mass spectrometry methodologies

  Lipidomics

Publications

1. A. Cutignano*, G Mamone, F Boscaino, A Ceriotti, M Maccaferri, G. Picariello. “Monitoring changes of lipid composition in durum wheat during grain development”, J. Cereal Sci. 2021, 97, 103131. https://doi.org/10.1016/j.jcs.2020.103131

2. R. Sacchi, A. Cutignano, G. Picariello, A. Paduano, A. Genovese, F. Siano, G. Nuzzo, S. Caira, C. Lubritto, P. Ricci, A. D’Auria, G. Di Pasquale, A. Motta, F. Addeo. “Olive oil from the 79 A.D. Vesuvius eruption stored at the Naples National Archaeological Museum (Italy)” NPJ Food of Science, 2020, 4, 19. https://doi.org/10.1038/s41538-020-00077-w

3. I. Ben Haj Yahia, Y. Zaouali, M. L. Ciavatta, A. Ligresti, R. Jaouadi, M. Boussaid and A. Cutignano* “Polyphenolic Profiling, Quantitative Assessment and Biological Activities of Tunisian Native Mentha rotundifolia (L.) Huds.” Molecules, 2019, 24, 2351. https://doi.org/10.3390/molecules24132351

4. E. Manzo, C. Gallo, R. Sartorius, G. Nuzzo, A. Sardo, P. De Berardinis, A. Fontana, A. Cutignano* “Immunostimulatory Phosphatidylmonogalactosyldiacylglycerols (PGDG) from the marine diatom Thalassiosira weissflogii: inspiration for a novel synthetic TLR-4 agonist” Mar. Drugs, 2019, 17, 103. https://doi.org/10.3390/md17020103

5. A. Cutignano*; E. Luongo; G. Nuzzo; D. Pagano; E. Manzo; A. Sardo; A. Fontana. “Profiling of complex lipids in marine microalgae by UHPLC/tandem mass spectrometry”, Algal Res., 2016, 17, 348-358. https://doi.org/10.1016/j.algal.2016.05.016

Contact

   MAIN RESEARCH SITE, POZZUOLI (NA)

  adele.cutignano@cnr.it

   PEC: adele.cutignano@pec.it

   (+39) 8675313/5185/5239

Scholar Google ResearchGate Profile View curriculum Editorial Board Member - Marine Drugs Orcid Publons Editorial Board Member - Phycology Review Editor Partner Biosearch

ICB Director

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Technical and administrative

Biography Skills Publications Contacts Biography Skills Publications Contacts

   RESEARCH SITE OF SASSARI

  francesco.defrancesco@cnr.it

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