Descrizione:

Antimicrobial resistance (AMR) is a global emergency related to public health due to its epidemiological and economic impact. The discovery of novel antimicrobial solutions is urgently needed to overcome this issue. Nanostructured drug delivery systems by the simultaneous delivery of multiple bioactive molecules can be a valid alternative to conventional treatment of infections. The nanosized carriers can establish a large contact area with the pathogen surface and by suited functionalization can bind receptors on its surface for a targeted drug delivery. The co-delivery of bioactives can result in an improved performance due to additive or synergistic effects and combined medicinal activities. In this proposal, bioactive phytocompounds in combination with antibiotics will be entrapped in nanocarriers, consisting of thermal-responsive carbon-dots or macrocyle-based nanoassemblies, for a multi drug treatment of infection sites. Dynamic simulations will allow to select nanocarriers and drugs for an effective loading and release. Antimicrobial, antibiofilm, anti-inflammatory and wound healing activity of the nanosystems will be evaluated and the more effective nanoconstructs will be embedded into biocompatible and biodegradable polymer thin films for a controlled and sustained local drug release. Drug release studies and biological activities will be tested to evaluate the use of films in the development of novel medical devices for the local treatment of infection and inflammation sites. The BIONANOF’ innovation deals with the development of novel medical devices based on antimicrobial/anti-inflammatory/antioxidant/wound healing nanoconstructs entrapped in biocompatible and biodegradable polymer films for a more effective multidrug local treatment of skin, oral cavity and ear infections. The designed devices might find application as removable and/or implantable medical devices to prevent or cure infected wounds.

Obiettivo del progetto:

The goal is the development of innovative, removable and/or implantable, medical devices based on polymer thin film drug delivery systems containing antibiotics and phytocompounds in nanocarriers, to prevent or treat infected wounds by a multidrug treatment.

Coordinatore e personale coinvolto:

Grazia Maria Letizia Consoli (coordinatore)
Tiziana Ferreri, Giuseppe Granata, Sonia Pedotti (partecipanti)

Ente capofila:

CNR

Enti partecipanti:

Università di Catania
Università di Messina

Link del progetto e/o tab, #:

#Prin2022PNRR

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