
Descrizione:
The project named CNR INVENIT involves seven other institutes of CNR. The Institute of Biomolecular Chemistry is integrated within a multidisciplinary platform for the identification of novel therapeutic targets and tools involved in neuronal and glial homeostasis, circuits, and plasticity, using cellular and animal models (from C. elegans-invertebrates to vertebrates), advanced materials, atomic-resolution cryo-electron microscopy, wide-screen epigenomics, closed-loop optogenetics, electrophysiology, calcium imaging, and novel synthetic and extractive technologies.

Obiettivo del progetto:
IIdentify defective mechanisms related to the endocannabinoid and gut microbiota system possibly underlying the severity and progression of rare neurological and musculoskeletal disorders
Coordinatore e personale coinvolto:
The coordinator of the ICB unit is Dr Fabio Arturo Iannotti. He graduated with a PhD in Neuroscience in 2010 from the University Federico II of Naples. To date, the leadership of the coordinator is guaranteed by his independent position as a senior Researcher at ICB and by his publication record in the field of endocannabinoids, plant-derived cannabinoids, and congener molecules in neurological and neuromuscular disorders. Since 2016, he has been the coordinator and principal investigator of several research studies supported by a European pharmaceutical company, competitive grants and nonprofit foundations.
Dr. Vincenzo Di Marzo published over 750 publications on the chemical and pharmacological properties of cannabinoids. He has gained a stable place in the list of about 6000 Highly cited world scientists since 2014. Currently, he is the director of the Joint International Unit for the Study of the microbiome, between the CNR and the Université Laval in Quebec City Canada.
Dr. Fabiana Piscitelli received a PhD in Neurobiology in 2013. She has great expertise in lipidomic analysis and other chemical analytical procedures, demonstrated by over 120 research articles published in international journals. She will contribute to the project execution by accomplishing the goals listed in Tasks.
Dr. Rosaria Villano holds a permanent position as a researcher at ICB. Her research interests include organic chemistry – organic synthesis and new synthetic methodologies. Based on this expertise, she will contribute to the execution of the experiments listed in Tasks. Dr Luigia Cristino research activity is focused on the role of cannabinoids and endocannabinoids in regulating neurotransmissions and plasticity in healthy and pathological conditions.
Ente capofila:
Istituto per la Ricerca e l’Innovazione Biomedica, IRIB-CNR, Catania
Enti partecipanti:
Istituto per la Ricerca e l’Innovazione Biomedica, IRIB-CNR, Catania
Istituto di Biochimica e Biologia Cellulare, IBBC-CNR, Napoli
Istituto di Neuroscienze, IN-CNR, Cagliari
Istituto di Genetica e Biofisica “Adriano Buzzati-Traverso” IGB-CNR, Napoli
Istituto di Chimica Biomolecolare (ICB), Pozzuoli (NA)
ISTITUTO DI BIOSCIENZE E BIORISORSE IBBR-CNR, Sede secondaria di Napoli
Istituto di Scienze Applicate e Sistemi Intelligenti “Eduardo Caianiello” (ISASI), Sede secondaria di Napoli ISASI-CNR
Istituto per i Polimeri, Compositi e Biomateriali, Sede Secondaria di Napoli/Portici IPCB-CNR, Napoli