Giovanni Loriga

1998 Master’s degree in Chemistry – University of Sassari (Italy).
2006 PhD Degree in Pharmaceutical Sciences (XVIII Cycle) – University of Genova (Italy).
1999/2002 Temporary research fellow at Neuroscienze Scarl, Pula (CA) (Italy).
2007/2011 Temporary research fellow at National Research Council (CNR), Biomedical Technologies Institute (ITB), Pula (CA) (Italy).
2011/2018 Researcher at National Research Council (CNR), Traslational Pharmacology Institute (IFT), Pula (CA) (Italy).
2012/2014 Head of NMR and Bioanalytical Technologies Platform, Pula (CA) (Italy).
2018/ongoing Researcher at National Research Council (CNR), Biomolecular Chemistry Institute (ICB), Sassari (Italy).
Teaching and tutoring:
2001/2017 Relator of several degree thesis in Pharmacy and Chemistry and Pharmaceutical Technology, Department of Pharmacy, University of Sassari (Italy).
2001/2007 Courses and seminars teacher, Department of Pharmacy, University of Sassari (Italy).
Research works:
Structure-activity relationships (SAR) study of potential antitumoral agents and analgesic compounds.
Preparation of compounds with potential biological activity. Design and synthesis of:
– central nervous system (CNS) active molecules: compounds active on opioid (μ, δ, and κ), cannabinoid (CB1 and CB2), and nicotinic receptors (α4β2);
– caspase’s inhibitors with potential application against immune and inflammatory disorders;
– “Proteolysis Targeting Chimeras” (PROTACs) as new antiviral agents.

1. F. Ulgheri, P. Spanu, F. Deligia, G. Loriga, M. P. Fuggetta, I. de Haan, A. Chandgudge, M. Groves, A. Domling. Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders. Eur. J. Med. Chem. 2022, 229, 114002. doi:10.1016/j.ejmech.2021.114002
2. G. Loriga, P. Lazzari, I. Manca, S. Ruiu, M. Falzoi, G. Murineddu, M. E. H. Bottazzi, G. Pinna, G. A. Pinna. Novel diazabicycloalkane delta opioid agonists. Bioorg. Med. Chem. 2015, 23(17), 5527-5538. doi:10.1016/j.bmc.2015.07.036
3. G. Loriga, P. Lazzari, S. Ruiu, G. Marchese, I. Manca, G. L. Casu, C. Dessì, G. A. Pinna, B. Asproni, G. Murineddu. Synthesis and biological evaluation of novel delta () opioid receptor ligands with diazatricyclodecane skeletons. Eur. J. Med. Chem. 2013, 69, 413-426. doi:10.1016/j.ejmech.2013.09.014
4. G. Murineddu, P. Lazzari, S. Ruiu, A. Sanna, G. Loriga, I. Manca, M. Falzoi, C. Dessì, M. M. Curzu, G. Chelucci, L. Pani, G. A. Pinna. Tricyclic Pyrazoles. 4. Synthesis and Biological Evaluation of Analogues of the Robust and Selective CB2 Cannabinoid Ligand 1-(2′,4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J. Med. Chem. 2006, 49(25), 7502-7512. doi:10.1021/jm060920
5. G. Loriga, I. Manca, G. Murineddu, G. Chelucci, S. Villa, S. Gessi, L. Toma, G. Cignarella, G. A. Pinna. Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors. Bioorg. Med. Chem. 2006, 14(3), 676-691. doi:10.1016/j.bmc.2005.09.045

  RESEARCH SITE OF SASSARI

   giovanni.loriga@cnr.it

  (+39) 0792841251