Researchers and technologists

Biography Skills Publications Contacts Biography

Dr Annarita Poli received her Bachelor Degree in Biological Science (Biomolecular curricula) at the University of Naples “Federico II” in 1997 (with 110/110 cum laude). In 2000, Dr Poli graduated with a PhD in Animal Biology at the Università degli Studi della Calabria discussing a thesis entitled “Biosynthesis and functional role of the nitric oxide in Sepia officinalis” carrying out the research activity at the Zoological Station “Anthon Dohrn”, Naples.

December 2001 –February 2020 Researcher at the Institute of Biomolecular Chemistry of C.N.R. in Pozzuoli (Naples).

Present position: since March 2020 Dr. Poli is a Senior Researcher.

Since January 2013 at present, she is a member of Reviewer Board of M.U.R. (Ministry of University and Research) and MiSE (Ministry of Economic Development) for the evaluation of scientific projects and CNR-Scientific Expert, respectively.

Since June 2015- Membership of the UNIVERSITY RESEARCH CENTER FOR THE STUDY OF EXTREME ENVIRONMENTS AND EXTREMOPHILES, Director Prof. Concetta Gugliandolo, at the Department of Biological and Environmental Sciences of the University of Messina.

Skills Taxonomy of Extremophiles
Microbial Exopolysaccharides
Fermentation Technology;
Extremozymes
Agro-vegetable and energy dedicated crops waste valorization
Astrobiology
Controlling of cultural heritage biodeterioration and biocleaning Publications

Annarita Poli, Enrico Esposito, Licia Lama, Pierangelo Orlando, Giancarlo Nicolaus, Francesca de Appolonia , Agata Gambacorta, Barbara Nicolaus (2006). Anoxybacillus amylolyticus sp. nov., a thermophilic amylase producing bacterium isolated from Mount Rittmann (Antarctica). Syst. Appl. Microbiol. Volume: 29 Issue: 4 Pages: 300-307 DOI: 10.1016/j.syapm.2005.10.003

https://pubmed.ncbi.nlm.nih.gov/16682297/

Annarita Poli, Hande Kazak, Bahar Gürleyendag, Giuseppina Tommonaro, Giuseppina Pieretti, Ebru Toksoy Öner, Barbara Nicolaus (2009). High level synthesis of levan by a novel Halomonas species growing on defined media. Carbohydrate Polymers Volume: 78 Issue: 4 Pages: 651-657 DOI: 10.1016/j.carbpol.2009.05.031 

https://www.sciencedirect.com/

Paola Di Donato, Gabriella Fiorentino, Gianluca Anzelmo, Giuseppina Tommonaro, Barbara Nicolaus, Annarita Poli. (2011). Re-use of vegetable wastes as cheap substrates for extremophile biomass production. Waste and Biomass Valorization, 2, 103-111.DOI 10.1007/s12649-011-9062-x

https://link.springer.com/article/10.1007/s12649-011-9062-x

Ilaria Finore, Annarita Poli, Paola Di Donato, Licia Lama, Antonio Trincone, Massimo Fagnano, Mauro Mori, Barbara Nicolaus, Annabella Tramice. Hemicellulose extract from Cynara cardunculus: a source of value-added biomolecules produced by xylanolytic thermozymes. 

Green Chemistry, 2016, 18, 2460-2472, doi: 10.1039/C5GC02774H

https://pubs.rsc.org/en/content/articlelanding/2016/gc/c5gc02774h

Ilaria Finore, Adrien Vigneron, Warwick F. Vincent, Luigi Leone, Paola Di Donato, Aniello Schiano Moriello, Barbara Nicolaus and Annarita Poli. Novel Psychrophiles and Exopolymers from Permafrost Thaw Lake Sediments. Microorganisms 2020, 8, 1282; doi:10.3390/microorganisms8091282

https://pubmed.ncbi.nlm.nih.gov/32842646/

Contacts    MAIN RESEARCH SITE, POZZUOLI (NA)

   apoli@icb.cnr.it

   PEC: annaritapoli@pec.it

   (+39) 081 8675311

ORCID: https://orcid.org/ 0000-0001-6465-4765 View curriculum

ICB Director

Researchers and technologists

Technical and administrative

Biography Skills Publications Contacts Biography Skills

• Targeted analysis of secondary metabolites from edible vegetable plants with the aim to value the expression of biologically active phytochemicals in studies of chemotaxonomy or agronomy interest
• Chemical and enzymatic synthesis of analogues of bioactive natural polyphenols
• Molecular Docking for the prediction of biological activities

Publications 1) Chemoenzymatic Synthesis and α-Glucosidase Inhibitory Activity of Dimeric Neolignans Inspired by Magnolol, Pulvirenti, L., Muccilli, V., Cardullo, N., Spatafora, C., Tringali, C. Journal of Natural Products, 2017, 80(5), pp. 1648–1657 https://doi.org/10.1021/acs.jnatprod.7b002502)Natural Isoflavones and Semisynthetic Derivatives as Pancreatic Lipase Inhibitors Cardullo, N., Muccilli, V., Pulvirenti, L., Tringali, C. Journal of Natural Products, 2021, 84(3), pp. 654–665 https://doi.org/10.1021/acs.jnatprod.0c013873)Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates, Russo, V., Continella, A., Drago, C., Pitari, G.M., Siracusa, L. PLoS ONE, 2021, 16(8 August), https://doi.org/10.1371/journal.pone.02558314) Influence of rootstock genotype on individual metabolic responses and antioxidant potential of blood orange cv. Tarocco Scirè, Modica, G., Pannitteri, C., Di Guardo, M., Continella, A., Siracusa, L. Journal of Food Composition and Analysis, 2022, 105, https://doi.org/10.1016/j.jfca.2021.1042465)An integrated approach for the characterization of wild Crocus species adopting phenotypical and phytochemical traits, Siracusa, L., Onofri, A., Galesi, R., Spampinato, G., Cristaudo, A. Phytochemistry, 2022, 202, https://doi.org/10.1016/j.phytochem.2022.113315 Contacts  RESEARCH SITE OF CATANIA   l.pulvirenti@icb.cnr.it   PEC: luanapulvirenti@pec.it  (+39) 0957338335ORCID: https://orcid.org/0000-0002-6073-7894 Scopus UniCt Researchgate View curriculum

ICB Director

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Head of the research site of Padova

Biography Skills Publications Contacts Biography

EDUCATION 1985 Graduated in Medicinal Chemistry with honours (Laurea in Chimica e Tecnologia Farmaceutiche), University of Padua, Italy.

CURRENT POSITION 2021 (1) to date Director of Research at CNR, Institute of Biomolecular Chemistry, Padova Unit, Padova, Italy.

INSTITUTIONAL RESPONSIBILITIES 2020 (1) to date Head of the Secondary Office (RSS) of ICB in Padua.

TEACHING ACTIVITIES 2011 to date Organic Chemistry and Biochemistry, degree course in Viticulture and Enology Science and Technology, University of Padova. 1998 to date supervision of graduate and PhD students.

MEMBERSHIPS OF SCIENTIFIC SOCIETIES Member of the ACS, APS, EPS, SCI, ItPS.

SCIENTIFIC INTERESTS study of the structure and interactions of biologically active peptides with proteins and how these interactions can be influenced by the presence of small molecules. Particular attention is paid to molecules with osmolytic properties and how these can interfere and counteract protein misfolding.

The research activities are aimed at: i) development and validation of analytical methodologies (SRCD, fluorescence, NMR) for the characterization and monitoring of peptide / small molecule interactions with proteins; ii) study of misfolding and protein aggregation processes in peptide or protein models in order to quickly identify a protective activity by different molecules; iii) protein-protein interaction studies and development of molecules capable of modulating this activity; iv) design and characterization of peptides for the active targeting and delivery of anticancer drugs.

Skills Peptide synthesis
Protein interactions
Protein misfolding
Circular Dichroism
Synchrotron radiation circular dichroism Publications

Tagliavini, V.; Honisch, C.; Serratì, S.; Azzariti, A.; Bonchio, M.; Ruzza, P.; Carraro, M. Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design. RSC Adv. 2021, 11, 4952-4957.

Ruzza, P.; Honisch, C.; Hussain, R.; Siligardi, G. Free Radicals and ROS Induce Protein Denaturation by UV Photostability Assay. Int. J. Mol. Sci. 2021, 22.

Parrasia, S.; Rossa, A.; Varanita, T.; Checchetto, V.; De Lorenzi, R.; Zoratti, M.; Paradisi, C.; Ruzza, P.; Mattarei, A.; Szabò, I.; Biasutto, L. An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors. Pharmaceuticals 2021, 14, 129.

Honisch, C.; Ragazzi, E.; Hussain, R.; Brazier, J.; Siligardi, G.; Ruzza, P. Interaction of a Short Peptide with G-Quadruplex-Forming Sequences: An SRCD and CD Study. Pharmaceutics 2021, 13.

Honisch, C.; Osto, A.; de Matos, A. D.; Vincenzi, S.; Ruzza, P. Isolation of a tyrosinase inhibitor from unripe grapes juice: A spectrophotometric study. Food Chem. 2020, 305.

Contacts   RESEARCH SITE OF PADOVA

   paolo.ruzza@icb.cnr.it – paolo.ruzza@unipd.it

   (+39) 049 8275282 – fax: (+39) 049 827 5239

ORCID: 0000-0002-5596-9295 Unipd profile View curriculum

ICB Director

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Claudia Sanfilippo was born in Catania in 1965. She graduated with honors in Organic Chemistry in 1990 at the University of Catania. In the 1998 she obtained her PhD in Organic Chemistry at the Department of Chemical Sciences of the University of Catania. From 1991 to 1993 she worked at the CNR-Istituto per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico-Farmaceutico of Catania granted by a CNR research fellowship. Since 1994 she is a researcher working at CNR-Istituto di Chimica Biomolecolare (ICB-CNR), UOS of Catania. The scientific activity is mainly focused on the use of enzymatic catalysis for the asymmetric synthesis of chiral and prochiral organic molecules.

Skills Biocatalysis
Enzymes
Oxygenases
Lipases
Chiral
Compounds Publications

• Biondi, D.M., Sanfilippo, C., Patti, A., Stereospecific epoxidation of limonene catalyzed by peroxygenase from oat seed. Antioxidants, 2021, 10(9), 1462

• Sanfilippo, C., Patti, A., Biocatalytic regio- and stereoselective access to ω-3 endocannabinoid epoxides with peroxygenase from oat flour. Bioorganic Chemistry, 2021, 113, 105014

• Patti, A., Sanfilippo, C., Breaking molecular symmetry through biocatalytic reactions to gain access to valuable chiral synthons. Symmetry, 2020, 12(9), 1454

• Sanfilippo, C., Paterna, A., Biondi, D.M., Patti, A. Lyophilized extracts from vegetable flours as valuable alternatives to purified oxygenases for the synthesis of oxylipins. Bioorganic Chemistry, 2019, 93, 103325

• Sanfilippo, C., Paternò, A.A., Patti, A. Resolution of racemic amines via lipase-catalyzed benzoylation: Chemoenzymatic synthesis of the pharmacologically active isomers of labetalol. Molecular Catalysis, 2018, 449, pp. 79–84

Contact    RESEARCH SITE OF CATANIA

   claudia.sanfilippo@icb.cnr.it

  (+39) 095 7338330

ORCID: 0000-0001-6969-3974;

Author ID: 6601958884 View curriculum

ICB Director

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Publications

 

 

Contacts    RESEARCH SITE OF SASSARI

   daniele.sanna@icb.cnr.it

  PEC: daniele.sanna@arubapec.it

   (+39) 079 2841207

ORCID: 0000-0001-9299-0141

Researcher ID: -9021-2011 View curriculum

ICB Director

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Maria Cristina Sini is graduated in Biological Science at University of Sassari in 2000 and received her PhD Degree in Biochemistry, Biology and Molecular Biotechnology at the University of Sassari in 2006. She is currently researcher at Institute of Biomolecular Chemistry (ICB), CNR and affiliated with IRGB, CNR.

Winner of a national research grant from the Italian Melanoma Intergroup (IMI) as principal investigator and of the Advanced Training Program of the Sardinia Region “Master and Back” too. She contributes as co-investigator in several national and international scientific research projects. She is currently member of the International Consortium ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles) and member of the IMI (Italian Melanoma Intergroup) scientific committee .

Her research activity is actually based on clinical cancer genetics and translational medicine aimed to identify new molecular targets for the development of targeted therapy using Next Generation Sequencing (NGS) technologies with multigene panels. She is author of several peer-reviewed publications and several book chapters.

Skills Molecular Biology
Cancer
Cancer biomarkers
Translational Medicine
NGS Publications

Manca, A, Sini M.C., Cesinaro, AM, Portelli, F, Urso, C, Lentini, M, Cardia, R, Alos, L, Cook, M, Simi, S, Paliogiannis, P, De Giorgi, V, Cossu, A, Palmieri, G, Massi, D. NGS-Based Analysis of Atypical Deep Penetrating Nevi. CANCERS (2021), ISSN: 2072-6694, DOI: 10.3390/cancers13123066

https://biblioproxy.cnr.it:3009/wos/woscc/full-record/WOS:000666749300001

https://pubmed.ncbi.nlm.nih.gov/34205480/

Sini, M.C., Doneddu, V., Paliogiannis P., Casula M., Colombino M., Manca A., Botti G., Ascierto, PA., Lissia A., Cossu A., Palmieri G. Genetic alterations in main candidate genes during melanoma progression. ONCOTARGET (2018), vol. 9, p. 8531-8541, ISSN: 1949-2553,

DOI: 10.18632/oncotarget.23989

https://pubmed.ncbi.nlm.nih.gov/29492214/

Liu, Pin, Ge, Mengmeng, Hu, Junjie, Li, Xiaolei, Che, Li, Sun, Kun, Cheng, Lili, Huang, Yuedong, Pilo, Maria G, Cigliano, Antonio, Pes, Giovanni M, Pascale, Rosa M, Brozzetti, Stefania, Vidili, Gianpaolo, Porcu, Alberto, Cossu, Antonio, Palmieri, Giuseppe, Sini, Maria C, Ribback, Silvia, Dombrowski, Frank, Tao, Junyan, Calvisi, Diego F, Chen, Ligong, Chen, Xin. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. HEPATOLOGY (2017), vol. 66, p. 167-181, ISSN: 1527-3350, DOI: 10.1002/hep.29183

https://biblioproxy.cnr.it:3009/wos/woscc/full-record/WOS:000403883100016

https://pubmed.ncbi.nlm.nih.gov/28370287/

Colombino M, Sini M.C., Lissia A, De Giorgi V, Stanganelli I, Ayala F, Massi D, Rubino C, Manca A, Paliogiannis P, Rossari S, Magi S, Mazzoni L, Botti G, Capone M, Palla M, Ascierto PA, Cossu A, Palmieri G, Italian Melanoma Intergroup (IMI). Discrepant alterations in main candidate genes among multiple primary melanomas . JOURNAL OF TRANSLATIONAL MEDICINE (2014), ISSN: 1479-5876, DOI: 10.1186/1479-5876-12-117

https://biblioproxy.cnr.it:3009/wos/woscc/full-record/WOS:000336931000001

https://pubmed.ncbi.nlm.nih.gov/24885594/

M.C. Sini , A Manca, A Cossu, M Budroni, G Botti, P A Ascierto, F Cremona, A Muggiano, S D’Atri, M Casula, P Baldinu, G Palomba, A Lissia, F Tanda, G Palmieri. Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma. BRITISH JOURNAL OF DERMATOLOGY (2008), vol. 158(2), p. 243-250, ISSN: 0007-0963, DOI: 10.1111/j.1365-2133.2007.08310.x

https://biblioproxy.cnr.it:3009/wos/woscc/full-record/WOS:000252495000006

https://pubmed.ncbi.nlm.nih.gov/18028495/

Contacts  RESEARCH SITE OF SASSARI

   mariacristina.sini@cnr.it

  PEC: mariacristina.sini@pec.it

  (+39) 2841314 – Cell (+39) 3471196016

Web of Science ResearcherID: AAY-3030-2020
ORCID: https://orcid.org/0000-0003-2796-6166
SCOPUS AU-ID: 6603705830 View curriculum

ICB Director

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Biography Skills Publications Contacts Biography

Laura Siracusa obtains her PhD in Organic Chemistry in 1999 defending a thesis on “Phosphorous containing organic compounds with potential antitumor activity”. In 2000-2001, she is a post-doc research assistant at Trinity College Dublin (TCD, Ireland) then at the Department of Chemistry of the University of Bristol (UK), working on cholic acid-based supramolecular chemistry under the supervision of Prof. A.P. Davis . Back to Italy and after a couple of years as research assistant at ICB-CNR and University of Catania, she joins the ICB-CNR “Natural Products and Food Chemistry” team as tenured researcher in January 2008. She is adjunct Professor of Phytochemistry (Department of Drug Science) and Food Chemistry (Department of Agriculture, Food and Environment) at the University of Catania. From year 2020, she is qualified as Associate Professor in the scientific area CHIM/10 (Food Chemistry).

Skills Metabolic profiling
Analysis of complex matrices
Metabolic response
Targeted and untargeted multi instrumental food analysis Publications

Venera Russo, Alberto Continella, Carmelo Drago, Alessandra Gentile, Stefano La Malfa, Claudio Giovanna Leotta, Luana Pulvirenti, Giuseppe Ruberto, Giovanni Mario Pitari, Laura Siracusa. Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates. PLoSONE 2021, 16, e0255831. 

DOI: 10.1371/journal.pone.0255831

Cristina Patanè, Salvatore L. Cosentino, Silvio Calcagno, Luana Pulvirenti, Laura Siracusa. How do sowing time and plant density affects the pigments safflomins and carthamin in the florets of safflower? Industrial Crops and Products 2020, 148, 112313.

DOI: 10.1016/j.indcrop.2020.112313

Laura Siracusa, Cristina Patané, Valeria Rizzo, Salvatore Luciano Cosentino, Giuseppe Ruberto. Targeted secondary metabolic and physico-chemical traits analysis to assess genetic variability within a germplasm collection of “long storage” tomatoes. Food Chemistry 2018, 244, 275-283.

DOI: 10.1016/j.foodchem.2017.10.043

 

C. Pannitteri, A. Continella, L. Lo Cicero, A. Gentile, S. La Malfa, E. Sperlinga, E.M. Napoli, T. Strano, G. Ruberto, L. Siracusa. Influence of postharvest treatments on qualitative and chemical parameters of Tarocco blood orange fruits to be used for fresh chilled juice. Food Chemistry 2017, 230,441-447.

DOI: 10.1016/j.foodchem.2017.03.041

 

 

Laura Siracusa, Fabio Gresta, Giovanni Avola, Emidio Albertini, Lorenzo Raggi, Gianpiero Marconi, Giuseppe Ruberto. Agronomic, chemical and genetic variability of saffron of different origin by LC-UV-VIS-DAD and AFLP analyses. Genetic Resources Crop Evolution 2013, 60, 711-721.

DOI: 10.1007/s10722-012-9868-9

Contacts   RESEARCH SITE OF CATANIA

   laura.siracusa@icb.cnr.it

   PEC: laurasiracusa@pec.it

   (+39) 095 7338348

ORCID ID: 0000-0003-3771-3138 Di3a UNICT Dsf UNICT Researchgate View curriculum Macrothink

ICB Director

Researchers and technologists

Technical and administrative

Biography Skills Publications Contacts Biography

• Present position: Researcher at the Institute for Biomolecular Chemistry-CNR section of Sassari;
• 2007-2009 – Research fellow (Master & Back project) at the Institute for Biomolecular Chemistry-CNR section of Sassari
• 2005-2006 – Ligbank® scientific officer and Postdoctoral researcher in the research group of Prof. Simon Woodward at Organic Chemistry Department, University of Nottingham (UK);
• 2000-2004 –PhD in the research of Prof. Walter Leitner at the Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr and Institut für Technische und Makromolekulare Chemie”, RWTH Aachen, (Germany);
• 2000 – Degree in Organic and Analytical Chemistry (University of Sassari)

Skills Organic synthesis
Catalysis
Green Chemistry
Medicinal Chemistry Publications

• A. Porcu, C. Lobina, D. Giunta, Maurizio Solinas, C. Mugnaini, M.P. Castelli, “In vitro and in vivo pharmacological characterization of SSD114, a novel GABA_B positive allosteric modulator”, Eur. J. Pharmacol., 2016, 791, 115–123.

http://www.scopus.com/inward/record.url?eid=2-s2.0-84984856810&partnerID=MN8TOARS

• Maurizio Solinas, A. Pfaltz, P. G. Cozzi, W. Leitner, “Enantioselective Hydrogenation of Imines in Ionic Liquid/Carbon Dioxide Media”, J. Am. Chem. Soc., 2004, 126, 16142-16147.

http://www.scopus.com/inward/record.url?eid=2-s2.0-10344225142&partnerID=MN8TOARS

• Maurizio Solinas, J. Jiang, O. Steltzer, W. Leitner, “Organometallic “Cartridge” Catalysis Using a Poly(ethyleneglycol)-Modified Phosphine Ligand and Supercritical Carbon Dioxide as a Phase Switch”_, Angew. Chem., Int. Ed., 2005, 44, 2291–2295 (HOT paper).

http://www.scopus.com/inward/record.url?eid=2-s2.0-17644424685&partnerID=MN8TOARS

• Maurizio Solinas, R. E. Meadows, C. Wilson, A. J. Blake, S. Woodward, “Efficient Synthesis of 2-Methyl Derivatives of 1,1-Bi(2-naphthol) and 1,1-Bi(2-phenol)”, Eur. J. Org. Chem., 2007, 10, 1613-1623.

http://www.scopus.com/inward/record.url?eid=2-s2.0-34250659794&partnerID=MN8TOARS

• Maurizio Solinas, B. Sechi, G. Chelucci, S. Baldino, J. R. Pedro, G. Blay, “Synthesis and application of new iminopyridine ligands in the enantioselective palladium-catalyzed allylic alkylation”, J. Mol. Catal. A: Chemical, 2014, 385, 73–77.

http://www.scopus.com/inward/record.url?eid=2-s2.0-84894060245&partnerID=MN8TOARS

Contacts   RESEARCH SITE OF SASSARI

   maurizio.solinas@icb.cnr.it

   (+39) 079 2841219

ORCID: 0000-0003-4998-7996
Scopus Author ID: 7003781633 View curriculum

ICB Director

Researchers and technologists

Technical and administrative

Biography Skills Publications Contacts Biography

Technologist, third level – Admistrative sector
Bureaucratic and Administrative expertises, such as:
– Economic-financial planning support and collaboration applied to the various regional, national and European financial research programs;
– Planning and Filling of granted research projects;
– Qualified knowledges on specialistics software applications for all administrative, economic, financial and accounting obligations such as “SIGLA” and “CNR missions”;
– Planning and filling of administrative forms.

Skills Organizational and financial management
Economic-accounting management
Administrative skills
Publications Contacts

  RESEARCH SITE OF CATANIA

   lucia.sollima@cnr.it

  (+39) 095 7338336

View curriculum

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Dr. Stefano Tartaggia received his M.Sc. degree in Chemistry and Environmental Compatibility in 2007 and his PhD in Chemical Sciences in 2011 at the Ca ‘Foscari University of Venice. During his doctoral studies, he performed part of his research work at the University of Kaiserslautern in Germany. From 2011 to 2015, he worked as postdoctoral researcher at the Ca ‘Foscari University of Venice to develop advanced synthetic methodologies for the preparation of active pharmaceutical ingredients in collaboration with industry partners. From 2015 to 2020, he was employed at the National Cancer Institute CRO Aviano, where he designed new biosensing platforms for the therapeutic monitoring of anticancer drugs and circulating biomarkers aimed at improving the efficacy of anticancer therapies. From 2020 to 2022, he worked within important food and pharmaceutical corporates, covering the roles of chemical analyst and R&D scientist to develop analytical methods and innovative industrial processes for the manufacturing of generic drugs. In 2022, he joined the Institute of Biomolecular Chemistry of the National Research Council in the Padua site, where he currently work on the synthesis and characterization of functionalized peptides.

Skills Organic synthesisActive pharmaceutical ingredientsSurface plasmon resonanceAnalytical method developmentAptamersBioconjugation PublicationsTartaggia, S.; Meneghello, A.; Bellotto, O.; Poetto, A.S.; Zanchetta, M.; Posocco, B.; Bunka, D.; Polo, F.; Toffoli, G. “An SPR Investigation Into The Therapeutic Drug Monitoring Of The Anticancer Drug Imatinib With Selective Aptamers Operating In Human Plasma” Analyst 2021, vol. 146, pp. 1714-1724. https://doi.org/10.1039/D0AN01860KDinel, M. P.; Tartaggia, S.; Wallace, G. Q.; Boudreau, D.; Masson, J. F.; Polo, F. “The Fundamentals Of Real-Time Surface Plasmon Resonance/Electrogenerated Chemiluminescence” Angewandte Chemie International Edition 2019, vol. 58, pp. 18202-18206. https://doi.org/10.1002/anie.201909806Tartaggia, S.; Alvau, M. D.; Meneghello, A.; Casetta, B.; Polo, F.; Toffoli, G. “Practical Fluorimetric Assay for the Detection of Anticancer Drug SN-38 In Human Plasma”, Journal Of Pharmaceutical And Biomedical Analysis 2018, vol. 159, pp. 73-81. https://doi.org/10.1016/j.jpba.2018.06.032Tartaggia, S.; Fogal, S.; Motterle, R.; Ferrari, C.; Pontini, M.; Aureli, R.; De Lucchi, O. “Chemoenzymatic Synthesis of d-keto-b-hydroxy Esters as Useful Intermediates for Preparing Statins”, European Journal Of Organic Chemistry 2016, pp. 3162-3165. http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201600268/fullTartaggia, S.; Ferrari, C.; Pontini, M.; De Lucchi, O. “A Practical Synthesis of Rosuvastatin and Other Statin Intermediates”, European Journal Of Organic Chemistry 2015, pp. 4102-4107. http://doi.wiley.com/10.1002/ejoc.201500356Contacts   RESEARCH SITE OF PADOVA   stefano.tartaggia@cnr.it  (+39) 0498275246ORCID: 0000-0003-4835-058X View curriculum

ICB Director

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Head of the research site of Sassari

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Publications

 

 

Contacts   RESEARCH SITE OF SASSARI

   pietro.spanu@cnr.it

 (+39) 079-2841222  – 079-2841203 View curriculum

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Researcher full time at Institute of Biomolecular Chemistry, CNR.

1994. Degree, University of Naples, Federico II in Biological Science with 110/110 with laude, title of thesis: “Accumulation and effects of cadmium and zinc in Idotea baltica”.

1995-2007. She was involved in research activity on isolation, characterization and biological activity of natural products at ICB with fellowships.

2003. Master of first level in “Chemistry and toxicity of biologically active metabolites”, Second University of Naples, with 110/110

2008 to date: Researcher for National Council Research of Italy at the Institute of Biomolecular Chemistry (ICB-CNR)

2011: Member of Scientific Board of the International PhD Programme “Environment, Resources and Sustainable Development” (http://www.ersd.uniparthenope.it/) at the “Parthenope” University of Naples. Appointment for “Analysis of risk in biotechnological processes” – Course at Parthenope University of Naples; A.A. 2011/2012.

2012: Appointment for “Analysis of risk in biotechnological processes” – Course at Parthenope University of Naples. A.A. 2012/2013.

Total publications: 87 peer-reviewed papers, Reviewer of international scientific journals: Molecules, Marine Drugs, Microbial Ecology, Cancers, Pharmaceutical Biology, Natural Product Research, Foods, American Society for Microbiology.

Editor of the book: Quorum Sensing: Molecular Mechanism and Biotechnological Application. 2019. Ed. Tommonaro Giuseppina, Publisher: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 125 LONDON WALL, LONDON EC2Y 5AS, ENGLAND.

Skills Chemistry of natural compounds
Biological activity assays (antimicrobial, cytotoxicity, AChE inhibition, antioxidant)
Marine organisms
Sponge- and plant- associated microorganisms
Quorum sensing
Nutritional capacities evaluation of tomato and new tomato hybrids Publications

1) Tramice, A.; Cutignano, A.; Iodice, A.; Poli, A.; Finore, I.; Tommonaro, G. (2021). Involvement of a Quorum Sensing Signal Molecule in the Extracellular Amylase Activity of the Thermophilic Anoxybacillus amylolyticus. Microorganisms, 9, 819. https://pubmed.ncbi.nlm.nih.gov/33924442/

2)Tommonaro, G.; Abbamondi, G.R.; Nicolaus, B.; Poli, A.; D’Angelo, C.; Iodice, C.; De Prisco, R. (2021). Productivity and Nutritional Trait Improvements of Different Tomatoes Cultivated with Effective Microorganisms Technology. Agriculture ,11, 112. https://www.mdpi.com/2077-0472/11/2/112

3) Basaran TI, Berber D, Gökalsın B, Tramice A, Tommonaro G, Abbamondi GR, Erginer Hasköylü M, Toksoy Öner E, Iodice C and Sesal NC (2020) Extremophilic Natrinema versiforme Against Pseudomonas aeruginosa Quorum Sensing and Biofilm. Front. Microbiol. 11:79. doi: 10.3389/fmicb.2020.00079. https://pubmed.ncbi.nlm.nih.gov/32117114/

4)Giordano A. and Tommonaro G. (2019). Curcumin and Cancer. Nutrients 2019, 11(10), 2376. https://pubmed.ncbi.nlm.nih.gov/31590362/

5) Tommonaro G., García-Font N., Vitale R.M., Pejin B., Iodice C., Cañadas S., Marco-Contelles J., Oset-Gasque M.J. (2016). Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer’s disease. Eur J Med Chem, 122, 326-338. https://pubmed.ncbi.nlm.nih.gov/27376495/

Contacts   MAIN RESEARCH SITE, POZZUOLI (NA)

   gtommonaro@icb.cnr.it;

   PEC: gtommonaro@pec.it

   (+39) 0818675029 (studio) – Cell: (+39) 3311557336

ORCID ID: 0000-0002-9613-1843;
Web of Science Researcher ID: AAX-9587-2021 View curriculum

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