Emiliano Manzo

Dr. Manzo Emiliano got his degree in Chemistry at the University of Naples ’Federico II’ on 19 July 1996 with the votes 110/110 cum laude. On 2001 he obtained his Ph.D. in “Chemical Sciences” (Cycle XIII) at the University of Naples “Federico II” discussing the thesis “Interactions between carbohydrates and metal ions”. Since 2001 he is Researcher and since January of 2021 he is Senior Researcher at the Institute of Biomolecular Chemistry of the National Research Council (CNR). The research activity concerns the chemical synthesis of natural products, the characterization of natural substances of marine, terrestrial and microbial origin and the study of the chemical-physical behavior of bioactive lipid metabolites in water. In particular, the activities carried out are: a) chemical synthesis of secondary metabolites of marine and terrestrial origin aimed at structural confirmation and the need to have sufficient amount of product to investigate biological activity and for any pharmacological developments b) isolation of new secondary metabolites from natural extracts by chromatographic techniques; c) chemical characterization of the isolated molecules by spectrometric (LCMS, ESIMS) and spectroscopic (NMR, IR, UV, CD) methods; d) study of supramolecular aggregates of lipid bioactive substances in aqueous environment. This study is aimed at the identification and preparation of molecules to be proposed as new lead-compounds in the pharmaceutical field.

1. Emiliano Manzo,* Laura Fioretto, Carmela Gallo, Marcello Ziaco, Genoveffa Nuzzo, Giuliana D’Ippolito, Assunta Borzacchiello, Antonio Fabozzi, Raffaele De Palma, Angelo Fontana “Preparation, Supramolecular Aggregation and Immunological Activity of the Bona Fide Vaccine Adjuvant Sulfavant S” Marine Drugs (ISSN): 16603397), 2020, 18 (9), 451; doi: 10.3390/md18090451

2. Emiliano Manzo, Carmela Gallo, Rossella Sartorius, Genoveffa Nuzzo, Angela Sardo, Piergiuseppe De Berardinis, Angelo Fontana, Adele Cutignano “Immunostimulatory phosphatidylmonogalactosyldiacylglycerols (PGDG) from the marine diatom Thalassiosira weissflogii: inspiration for a novel synthetic Toll-like receptor 4 agonist”. Marine Drugs (ISSN): 16603397), 2019, 17, 103; doi:10.3390/md17020103

3. Emiliano Manzo,* Carmela Gallo, Laura Fioretto, Genoveffa Nuzzo, Giusi Barra, Dario Pagano, Irene Russo Krauss, Luigi Paduano, Marcello Ziaco, Marina Della Greca, Raffaele De Palma, Angelo Fontana “Diasteroselective colloidal self-assembly affects the immunological response of the molecular adjuvant Sulfavant”. ACS Omega (ISSN): 24701343), 2019, 4 (4), 7807-7814. doi: 10.1021/acsomega.8b03304

4. Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta
   Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A. Izzo,
   Vincenzo Di Marzo, Stefania Petrosino “A glucuronic acid-palmitoylethanolamide conjugate (GLUPEA) is an innovative drug delivery system and a potential bioregulator” Cells, 2021, 10(2), 450; doi: 10.3390/cells10020450

5. Emiliano Manzo, Adele Cutignano, Dario Pagano, Carmela Gallo, Giusi Barra, Genoveffa Nuzzo, Clementina Sansone, Adrianna Ianora, Konrad Urbanek, Daniela Fenoglio, Francesca Ferrera, Cinzia Bernardi, Alessia Parodi, Giuseppe Pasquale, Antonio Leonardi, Gilberto Filaci, Raffaele De Palma and Angelo Fontana “A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response”. Scientific Reports (Nature) (ISSN): 2045-2322), 2017; 7: 1-10; doi: 10.1038/s41598-017-05969-8