Medical compounds; Giovanni M. Pitari; Claudia G. Leotta; Carmelo Drago; Giovanni Nicolosi, WO2019008537A9 (PCT/IB2018/054981)
AUTHORS:
Giovanni M. Pitari; Claudia G. Leotta; Carmelo Drago; Giovanni Nicolosi
INTERNATIONAL PUBLICATION NUMBER:
WO2019008537A9
International Application Number: PCT/IB2018/054981
Holder: Vera Salus Ricerca S.r.l.
ABSTRACT:
The invention is related to a medical compound comprising a flavone scaffold and appropriate synthetic chemical modules that increase its bioavailability, tolerability and biological efficacy. The compounds of the invention therefore constitute a semisynthetic library of small molecules of natural origin that can be used for the development of innovative drugs and the therapy of human pathologies. In particular, the compounds object of the invention can be used for the treatment of malignant tumors, more particularly of malignant epithelial tumors and carcinomas of the lung, colorectal, breast and prostate and of melanoma, or for the treatment of inflammatory, neurodegenerative diseases, pain, microbial and oxidative stress.
Research field: Human health and well-being
Branch Site: Research Site, Catania (CT)
