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- claudia.honisch@cnr.it
- 049 8275246
Claudia Honisch
Experience & Activities
Claudia Honisch received her master’s degree in Pharmacy at the University of Padua on March 7th 2016, with an experimental thesis carried out as part of the Erasmus Project at Universität Regensburg (DE) entitled “Synthesis and pharmacological characterization of cabamoylguanidine-type histamine H2 receptor agonists “under the supervision of Prof. Armin Buschauer. In June 2016 she obtained the Qualification to Practice the Profession of Pharmacist. In September 2016 she started a scholarship at ICB-CNR Padua research site aimed at the “Characterization of thermal muds” of the Euganean thermal district. In October 2017 she started the PhD course in Molecular Sciences, curriculum Chemical Sciences, at the Chemistry Department of the University of Padua working on a project entitled “Aggregating proteins and their interaction with chemical chaperones” under the supervision of Prof. Paolo Ruzza (ICB-CNR). This work, which involved a close collaboration with the Diamond Light Source Ltd synchrotron facility (Didcot, U.K.) Beamline B23 for Circular Dichroism, was defended on March 24th 2021 in front of an international commission with the achievement of the title of Doctor Europaeus. Since September 2019 she holds a Research Grant within the AdriAquaNet Project, which is part of the EU Interreg V Italy-Croatia 2014-2020 Program. Within this context, the research activity has focused on the identification, synthesis and purification of peptide sequences with antimicrobial activity (antimicrobial peptides, AMPs) which allow to avoid the emergence of resistance to traditional antibiotics.
- peptide synthesis and characterisation
- conformational characterisation of peptides and proteins
- interaction of small molecules with peptides or proteins
- circular dichroism
- synchrotron radiation circular dichroism
- Honisch C, Osto A, Dupay A, Vincenzi S, Ruzza P, Isolation of a tyrosinase inhibitor from Verjuice: a spectrophotometric study, Food Chemistry (2019) 305, 125506 DOI: 10.1016/j.foodchem.2019.125506
- Honisch C, Donadello V, Hussain R, Peterle D, De Filippis V, Arrigoni G, Gatto C, Giurgola L, Siligardi G and Ruzza P, Application of circular dichroism and fluorescence spectroscopies to assess photo-stability of water-soluble porcine lens proteins, ACS Omega (2020) 5(8), 4293-4301, doi: https://doi.org/10.1021/acsomega.9b04234
- Honisch C, Hussain R, Siligardi G, Ruzza P, Influence of small molecules on the photo‐stability of water soluble porcine lens proteins. Chirality (2020) 1– 8. https://doi.org/10.1002/chir.23210
- Ruzza P, Honisch C, Hussain R, Siligardi G, Free radicals and ROS induce protein denaturation by UV photostability assay. International Journal of Molecular Sciences (2021) 22, 6512. https://doi.org/10.3390/ijms22126512
- Honisch C, Ragazzi E, Hussain R, Brazier J, Siligardi G, Ruzza P. Interaction of a Short Peptide with G-Quadruplex-Forming Sequences: An SRCD and CD Study. Pharmaceutics (2021) 13(8):1104. doi: 10.3390/pharmaceutics13081104.
RESEARCH SITE OF CATANIA
claudia.honisch@cnr.it
049 8275246
ORCID: 0000-0001-9720-6176
