Angela Patti

Angela Patti graduated with honors in Organic Chemistry at the University of Catania discussing a thesis on the aminoacidic composition of melanosomes from Rana esculenta L. and since 1988 has worked as researcher at the Istituto di Chimica Biomolecolare (ICB) belonging to Consiglio Nazionale delle Ricerche, Italy.

She was a visiting researcher in the Keele University, Staffordshire UK (1997, COST D1/0002/94 fellowship) and in Ludwig Maximilians Universitat in Munich in the Prof. Paul Knochel laboratory (1999-2000) under the Short-term mobility and NATO-CNR Senior Fellowships Programmes.

Her first scientific activity was focused on the chemistry of natural compounds, then she turned to the use of lipases in organic solvents as selective biocatalysts for the preparation of several enantiopure compounds belonging to different structural classes. Part of her research has been spent in the study of asymmetric reduction of chiral and prochiral diketones with different procedures (oxazaborolidine/borane promoted reduction and ruthenium-catalysed transfer hydrogenation) to give the corresponding optically active diols and in the development of new ferrocenyl-based ligands as efficient catalysts in asymmetric synthesis.

She currently works with several research groups applying her skills in the synthesis of chiral and achiral ferrocene compounds, biocatalytic reactions for the preparation of optically active compounds, chiral chromatography and NMR spectroscopy.

A) Patti, A. Green approaches to asymmetric catalytic synthesis

in Springer Briefs in Green Chemistry for Sustainability, DOI:10.1007/978-94-007-1454-0_1. Series Editor S.K. Sharma, Springer 2011

B) Sanfilippo, C.; Patti, A. Bioorg. Chem. 2021, 113, 105014

Biocatalytic regio- and stereoselective access to ω-3 endocannabinoid epoxides with peroxygenase from oat flour. DOI: 10.1016/j.bioorg.2021.105014

C) Saita, M. G.; Aleo, D.; Melilli, B.; Patti, A. Int. J. Pharm. 2019, 566, 674-679. DOI:10.1016/j.ijpharm.2019.06.025

Effect of cyclodextrin additives on azithromycin in aqueous solution and insight into the stabilization mechanism by sulfobutyl ether--cyclodextrin

D) Sanfilippo, C.; Paternò, A. A.; Patti, A. Mol. Catal. 2018, 449, 79-84

Resolution of racemic amines via lipase-catalyzed benzoylation: Chemoenzymatic synthesis of the pharmacologically active isomers of labetalol

E) Patti, A.; Pedotti, S. Eur. J. Org. Chem. 2014,624-630. DOI: 10.1002/ejoc.201301346

Synthesis of hybrid ferrocene-proline amides as active catalysts for asymmetric aldol reactions in water