Debora Paris

I have been working on NMR spectroscopy applied to metabolomics since 2004. I received the Graduation in Physics cum laude from the University of Napoli “Federico II” with the metabolomic study of the apoptotic process induced by ionizing radiation in human spheroids by Nuclear Magnetic Resonance spectroscopy. During the PhD period, I worked on the development and implementation of new spectroscopic tools for high throughput analysis in metabolomic investigations. The research activity covered the recent NMR improvements by applying and developing new metabolomic strategies for biomarkers discovery, including NMR data handling, peaks quantification and fast data acquisition. I received the Ph.D in Chemistry from the University of Napoli “Federico II”. I worked on different metabolomics projects, optimizing the acquisition of high-resolution NMR experiments, the processing and the quantification of spectral data. In particular, I focused on the analysis and spectral assignments of metabolic profiles arising from different kinds of biological samples: microalgae and microorganisms, in vivo cells, cell and tissue extracts, biofluids (blood, urine, saliva, respiratory condensate). I gained deep experience in the field of multivariate statistical analysis and statistical models for data projection and prediction, dataset integration and network analysis applied in different biological, medical and clinical fields.

• Di Costanzo, A#., Paris, D#*., Melck, D., Angiolillo, A., Corso, G., Maniscalco, M., Motta, A*. “Blood biomarkers indicate that the preclinical stages of Alzheimer’s disease present overlapping molecular features”. Scientific Reports 2020, 10 (1), art. no. 15612

• Paris, D., Palomba, L., Mirra, V., Borrelli, M., Corcione, A., Santamaria, F., Maniscalco, M., Motta, A. “Nmr profiling of exhaled breath condensate defines different metabolic phenotypes of non-cystic fibrosis bronchiectasis”. International Journal of Molecular Sciences 2020, 21 (22), art. no. 8600, pp. 1-23.

• Paris, D#., Maniscalco, M#., Motta, A. “Nuclear magnetic resonance-based metabolomics in respiratory medicine”. European Respiratory Journal 2018, 52 (4), art. no. 1801107

• Maniscalco, M.#, Paris, D#., Melck, D.J., Molino, A., Carone, M., Ruggeri, P., Caramori, G., Motta, A. “Differential diagnosis between newly diagnosed asthma and COPD using exhaled breath condensate metabolomics: A pilot study” European Respiratory Journal 2018, 51 (3), art. no. 1701825

• M Maniscalco#, D Paris#, D J Melck#, M D’Amato, A Zedda, M Sofia, C Stellato, A Motta. “Coexistence of Obesity and Asthma Determines a Distinct Respiratory Metabolic Phenotype”

Journal of Allergy and Clinical Immunology 2016, doi: 10.1016/j.jaci.2016.08.038