Antonio Trincone

Trincone Antonio

    • Researchers
  • 28 Gennaio 2015
  • 978

PERSONAL DETAILS


Profile: Primo ricercatore

Office location: Napoli

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Work phone #: 0818675095

Lab phone #: 0818675188

Mobile: 3388911306 

Biography:

Antonio Trincone graduated with honors in Pharmacy at the University of Naples discussing a thesis on biogenesis of membrane lipids of archaebacteria. He is currently a senior Researcher working since 1983 in Naples at the Istituto di Chimica Biomolecolare belonging to Consiglio Nazionale delle Ricerche, Italy. He has been Professor of Organic Chemistry in charge for several years at University of Salerno, Italy.

Antonio Trincone is Specialty Chief Editor of Marine Biotechnology in Frontiers Marine Science. He has been the editor of a book entitled Biocatalysis: Chemistry and Biology (Research Signpost, India), he is a reviewer for different scientific journals and research projects. He is part of Editorial Board of “Marine Drugs” and guest-edited two special issues for this journal. He has been recently asked to be part of Editorial Board of “Chemistry: an Indian Journal” and ISRN Biotechnology. He is the author of a page in SciTopics a site of Research Summaries by experts. Antonio Trincone participated to the Scientific Committee for the The 1st Symposium on Marine Enzymes and Polysaccharides (MEP’12) held in NhaTrang, Vietnam, from December 10th to 17th, 2012. He edited the book “Marine enzymes for biocatalysis: Sources, biocatalytic characteristics and bioprocesses of marine enzymes” Woodhead Publishing Series in Biomedicine No. 38 ISBN: 978-1-907568-80-0. Elsevier http://goo.gl/3MKZUS


 SCIENTIFIC ACTIVITIES


Interests:

Antonio Trincone is author of ca. 120 scientific publications (articles, reviews, book contributions) appeared in international leading scientific journals. Research activity started to be focused on structural determination of membrane lipids of extremophilic organisms and cyanobacteria.

He was a visiting researcher at the universities of Leicester (Prof. W.D. Grant) and Regensburg (Prof. K.O. Stetter). Soon scientific interest turned to the biocatalysis conducted with enzymes from extremophiles (extremozymes). In 1994 he started to be responsible of one of the research lines of the Institute “Chemical and biochemical studies of biocatalysis”. Great effort was centered to wild types of thermophilic glycosyl hydrolases from Sulfolobus solfataricus and to related mutated proteins, for (i) natural glycosides and oligosaccharides assembling, for (ii) study of stereochemistry of transglycosylation process and (iii) study of the mechanism of enzymatic action. The results led to interesting advances in chemical domain for the synthetic applications of thermophilic glycosynthases in the efficient production of branched beta-glucans useful in chemical and biological studies and other interesting biomolecules. Marine glycosyl hydrolases have to be seen as the current very promising topic to be added to the scientific interests of Antonio Trincone. In few years efforts towards the development within this subject produced half a dozen of scientific articles concerning just one organism, the sea hare Aplysia fasciata. All the glycosyl hydrolases (beta-galactosidase, alfa-glucosidase, beta-mannosidase, etc.) detected are useful in synthesis and/or hydrolysis of glycoconjugates and will surely be of interest for applications in biocatalysis for glycobiology.

Major publications:

http://scholar.google.it/citations?user=FMLm5p8AAAAJ&hl=it

Keyword:

 biocatalysis - glycosidases - enzymatic synthesis of glycosides 


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