Iannotti Fabio Arturo

Iannotti Fabio Arturo

    • Researchers
  • 03 Ottobre 2018
  • 1571


Profile: Research Fellow

Office location: Naples

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Lab phone #: 0818675303

Biography: Dr. Fabio Arturo Iannotti received his Bachelor Degree in Biotecnology Science (Medical curricula) at University of Naples "Federico II" in 2006 (with 110/110 cum laude). In 2010, Dr. Iannotti graduated with a PhD in Neuroscience at University of Naples "Federico II". The focus of his thesis was on the role of voltage-gated potassium channels Kv7 during the neuronal excitoxicity as well as skeletal muscle cell differentiation. During this time he also researched at the University of California-Davis assessing changes to the phosphorylation state of potassium channels in in vivo models of epilepsy. In 2011, he started his postdoc at the Institute of Biomolecular Chemistry (ICB)/ National Council of Research (CNR) and during this period he also visited the University of Reading, researching the potential involvement of TRP channels in epilepsy and muscle development. Since 2014, he was promoted to the position of research fellow at ICB. Dr. Iannotti has published many papers on these areas of research in international peer reviewed journals, and has received awards from both national and international scientific societies for his work.


Major publications

  1. Iannotti FA, Pagano E, Guardiola O, Adinolfi S, Saccone V, Consalvi S, Piscitelli F, Gazzerro E, Busetto G, Carrella D, Capasso R, Puri PL, Minchiotti G, Di Marzo V: Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne Muscular Dystrophy. Nature Commun. 2018 Sep 27;9(1):3950. doi: 10.1038/s41467-018-06267-1. 
  2. Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D'Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V. Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. Br J Pharmacol. 2018 Aug 3. doi: 10.1111/bph.14460. [Epub ahead of print] PubMed PMID: 30074247. 
  3. Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Bíró T, Harkany T, Taglialatela M, Di Marzo V. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. Proceedings of the National Academy of Sciences (PNAS) 2014 Jun 17;111(24):E2472-81. doi: 10.1073/pnas. 
  4. Iannotti FA, Barrese V, Formisano L, Miceli F, Taglialatela M Specification of Skeletal Muscle Differentiation by Repressor Element-1 Silencing Transcription Factor (REST)-Regulated Kv7.4 Potassium Channels. Molecular Biology of the Cell 2013 Feb;24(3):274-84. doi: 10.1091/mbc.E11-12-1044.
  5.  Iannotti FA, Panza E, Barrese V, Viggiano D, Soldovieri MV, Taglialatela M Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults. Journal of Pharmacology and Experimental Therapeutics 2010 Mar;332(3):811-20. doi: 10.1124/jpet.109.162800. 
  6. Iannotti FA, Hill CL, Leo A, Alhusaini A, Soubrane C, Mazzarella E, Russo E, Whalley BJ, Di Marzo V, Stephens GJ. The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem Neurosci. 2014 
  7. Iannotti FA, Di Marzo V, Petrosino S. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. Prog Lipid Res. 2016 Apr;62:107-28. doi: 10.1016/j.plipres.2016.02.002. Epub 2016 Mar 7. Review. PubMed PMID: 26965148. 
  8. Luisi R, Panza E, Barrese V, Iannotti FA, Viggiano D, Secondo A, Canzoniero LMT, Martire M, Annunziato L, Taglialatela M Activation of pre‐synaptic M‐type K+ channels inhibits [3H]d‐aspartate release by reducing Ca2+ entry through P/Q‐type voltage‐gated Ca2+channels. Journal of Neurochemistry 2009 Apr;109(1):168-81. doi: 10.1111/j.1471-4159.2009.05945.x. 
  9. Martire M, D'Amico M, Panza E, Miceli F, Viggiano D, Lavergata F, Iannotti FA, Barrese V, Preziosi P, Annunziato L, Taglialatela M Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes. Journal of Neurochemistry 2007 Jul;102(1):179-93. Epub 2007 Apr 16 
  10. Miceli F, Soldovieri MV, Iannotti FA, Barrese V, Ambrosino P, Martire M, Cilio MR, Taglialatela M. The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants. Front Pharmacol. 2011 Feb 1;2:2. doi: 10.3389/fphar.2011.00002. eCollection 2011. PubMed PMID: 21687499; PubMed Central PMCID: PMC3108560.


Muscular Degenerative diseases; Endocannabinoid System; Epilepsy; Ion Channels